Ex-vivo analysis of the bone microenvironment in bone metastatic breast cancer

Karen M. Bussard, Andrea M. Mastro

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


In humans, breast cancer has a predilection to metastasize to the skeleton. While the mechanism for preferential metastasis is unknown, the bone microenvironment likely provides a fertile soil for metastatic breast cancer cells. In order to examine the bone microenvironment ex-vivo following the formation of breast cancer metastases, several techniques may be employed: fluorescence stereomicroscopy, magnetic resonance imaging (MRI), microCT (μCT), immunohistochemistry, and cytokine arrays, to name a few. These methods allow for a comprehensive evaluation of the bone microenvironment during bone metastatic breast cancer. By identifying alterations in the bone niche caused by metastatic breast cancer cells, it may be possible to block or disrupt these factors through the use of targeted drugs. Appropriate therapeutic treatment would allow for an improved quality of life and longer survival time for individuals with bone metastatic breast cancer.

Original languageEnglish (US)
Pages (from-to)387-395
Number of pages9
JournalJournal of mammary gland biology and neoplasia
Issue number4
StatePublished - Dec 1 2009

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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