Exaggerated pressor response in relation to attenuated muscle temperature response during contraction in ischemic heart failure

Jianhua Li, Zhaohui Gao, Jian Lu, Jihong Xing

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

It is known that muscle temperature (T m) increases with exercise. The purpose of this study was to examine if contraction-induced increase in T m was altered in rats with heart failure (HF) induced by chronic myocardial infraction (MI) as compared with healthy control animals. A temperature probe was inserted in the triceps surae muscle to continuously measureT m throughout experiments. Static muscle contraction was induced by electrical stimulation of the sciatic nerve for 1 min. As baseline T m was 34°C, contraction increased temperature by 1.6 ± 0.18°C in nine health control rats and by 1.0 ± 0.15°C in 10 MI rats (P < 0.05 vs. control). Note that there were no differences in developed muscle tension and muscle weight between the two groups. In addition, muscle contraction increased mean arterial pressure by 23 ± 3 mmHg in control rats and by 31 ± 3 mmHg in MI rats (P < 0.05 vs. control). A regression analysis further shows that there is an inverse liner relationship between the pressor response and static contraction-induced increase in Tm. Our data suggest that T m increase evoked by contraction is impaired in MI rats. The abnormal alteration in Tm likely modifies the reflex cardiovascular responses in MI via mechanisms of temperature-sensitive receptors on muscle afferent nerves.

Original languageEnglish (US)
Article numberArticle 443
JournalFrontiers in Physiology
Volume3 NOV
DOIs
StatePublished - Dec 17 2012

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Heart Failure
Muscles
Temperature
Muscle Contraction
Muscle Tonus
Sciatic Nerve
Electric Stimulation
Reflex
Arterial Pressure
Regression Analysis
Weights and Measures
Health

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

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title = "Exaggerated pressor response in relation to attenuated muscle temperature response during contraction in ischemic heart failure",
abstract = "It is known that muscle temperature (T m) increases with exercise. The purpose of this study was to examine if contraction-induced increase in T m was altered in rats with heart failure (HF) induced by chronic myocardial infraction (MI) as compared with healthy control animals. A temperature probe was inserted in the triceps surae muscle to continuously measureT m throughout experiments. Static muscle contraction was induced by electrical stimulation of the sciatic nerve for 1 min. As baseline T m was 34°C, contraction increased temperature by 1.6 ± 0.18°C in nine health control rats and by 1.0 ± 0.15°C in 10 MI rats (P < 0.05 vs. control). Note that there were no differences in developed muscle tension and muscle weight between the two groups. In addition, muscle contraction increased mean arterial pressure by 23 ± 3 mmHg in control rats and by 31 ± 3 mmHg in MI rats (P < 0.05 vs. control). A regression analysis further shows that there is an inverse liner relationship between the pressor response and static contraction-induced increase in Tm. Our data suggest that T m increase evoked by contraction is impaired in MI rats. The abnormal alteration in Tm likely modifies the reflex cardiovascular responses in MI via mechanisms of temperature-sensitive receptors on muscle afferent nerves.",
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Exaggerated pressor response in relation to attenuated muscle temperature response during contraction in ischemic heart failure. / Li, Jianhua; Gao, Zhaohui; Lu, Jian; Xing, Jihong.

In: Frontiers in Physiology, Vol. 3 NOV, Article 443, 17.12.2012.

Research output: Contribution to journalArticle

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