@article{d8d83d2b742d46ba93922486f5cd9d7b,
title = "Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression",
abstract = "We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling{\textquoteright}s childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile β: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers.",
author = "Carey, {Meghan E.} and Juliette Rando and Stepan Melnyk and James, {S. Jill} and Nathaniel Snyder and Carolyn Salafia and Croen, {Lisa A.} and Fallin, {M. Daniele} and Irva Hertz-Picciotto and Heather Volk and Craig Newschaffer and Kristen Lyall",
note = "Funding Information: This research was supported by the Eunice Shriver Kennedy National Institute of Child Health and Human Development (NICHD) at the National Institutes of Health (NIH) (R21HD096356). The EARLI Study was funded by the National Institute of Environmental Health Sciences, the National Institute of Mental Health, the National Institute of Child Health and Human Development, and the National Institute of Neurologic Disease and Stroke (R01 ES016443; R24 ES030893), with additional funding from Autism Speaks (AS 5938). Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2022",
doi = "10.1007/s10803-022-05625-9",
language = "English (US)",
journal = "Journal of Autism and Developmental Disorders",
issn = "0162-3257",
publisher = "Springer New York",
}