Excitability of nodose ganglion cells and their role in vago-vagal reflex control of gastrointestinal function

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

A large body of evidence has demonstrated that vagal afferent neurones show non-uniform properties and that distinct neuronal populations can be identified within the nodose ganglia. Of particular interest is recent work illustrating the significant degree of plasticity displayed by vagal sensory neurones; alterations in vagal afferent neuronal excitability might be important in the development and maintenance of gastrointestinal pathological states. Although it is unclear whether such adaptations are mimicked centrally, recent studies suggest that tonic afferent vagal inputs act as a 'brake' on inputs to the dorsal motor nucleus of the vagus. It would be reasonable to assume, therefore, that plasticity in the excitability of vagal afferent neurones would have dramatic consequences for the regulation and modulation of gastrointestinal vago-vagal reflexes.

Original languageEnglish (US)
Pages (from-to)613-617
Number of pages5
JournalCurrent Opinion in Pharmacology
Volume3
Issue number6
DOIs
StatePublished - Jan 1 2003

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Nodose Ganglion
Afferent Neurons
Reflex
Sensory Receptor Cells
Maintenance
Population

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

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title = "Excitability of nodose ganglion cells and their role in vago-vagal reflex control of gastrointestinal function",
abstract = "A large body of evidence has demonstrated that vagal afferent neurones show non-uniform properties and that distinct neuronal populations can be identified within the nodose ganglia. Of particular interest is recent work illustrating the significant degree of plasticity displayed by vagal sensory neurones; alterations in vagal afferent neuronal excitability might be important in the development and maintenance of gastrointestinal pathological states. Although it is unclear whether such adaptations are mimicked centrally, recent studies suggest that tonic afferent vagal inputs act as a 'brake' on inputs to the dorsal motor nucleus of the vagus. It would be reasonable to assume, therefore, that plasticity in the excitability of vagal afferent neurones would have dramatic consequences for the regulation and modulation of gastrointestinal vago-vagal reflexes.",
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Excitability of nodose ganglion cells and their role in vago-vagal reflex control of gastrointestinal function. / Browning, Kirsteen.

In: Current Opinion in Pharmacology, Vol. 3, No. 6, 01.01.2003, p. 613-617.

Research output: Contribution to journalReview article

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AB - A large body of evidence has demonstrated that vagal afferent neurones show non-uniform properties and that distinct neuronal populations can be identified within the nodose ganglia. Of particular interest is recent work illustrating the significant degree of plasticity displayed by vagal sensory neurones; alterations in vagal afferent neuronal excitability might be important in the development and maintenance of gastrointestinal pathological states. Although it is unclear whether such adaptations are mimicked centrally, recent studies suggest that tonic afferent vagal inputs act as a 'brake' on inputs to the dorsal motor nucleus of the vagus. It would be reasonable to assume, therefore, that plasticity in the excitability of vagal afferent neurones would have dramatic consequences for the regulation and modulation of gastrointestinal vago-vagal reflexes.

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