Excitotoxicity-induced immediate surge in hippocampal prostanoid production has latent effects that promote chronic progressive neuronal death

Keisuke Yoshikawa, Yoshihiro Kita, Ayako Furukawa, Noriko Kawamura, Sanae Hasegawa-Ishii, Yoichi Chiba, Shiro Takei, Kei Maruyama, Takao Shimizu, Atsuyoshi Shimada

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Excitotoxicity is involved in neurodegenerative conditions. We investigated the pathological significance of a surge in prostaglandin production immediately after kainic acid (KA) administration [initial phase], followed by a sustained moderate elevation in prostaglandin level [late phase] in the hippocampus of juvenile rats. Numerous pyknotic hippocampal neurons were observed 72. h after KA treatment; this number remained elevated on days 10 and 30. Gross hippocampal atrophy was observed on days 10 and 30. Pre-treatment with indomethacin ameliorated neuronal death on days 10 and 30, and prevented hippocampal atrophy on day 30. Microglial response was moderated by the indomethacin pre-treatment. Blockade of only late-phase prostaglandin production by post-treatment with indomethacin ameliorated neuronal death on day 30. These findings suggest a role for initial-phase prostaglandin production in chronic progressive neuronal death, which is exacerbated by late-phase prostaglandin production. Blockade of prostaglandin production has therapeutic implications in preventing long-term neurological sequelae following excitotoxic brain damage.

Original languageEnglish (US)
Pages (from-to)373-381
Number of pages9
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume88
Issue number5
DOIs
StatePublished - May 1 2013

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Prostaglandins
Indomethacin
Kainic Acid
Atrophy
Neurons
Rats
Hippocampus
Brain

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Cell Biology

Cite this

Yoshikawa, Keisuke ; Kita, Yoshihiro ; Furukawa, Ayako ; Kawamura, Noriko ; Hasegawa-Ishii, Sanae ; Chiba, Yoichi ; Takei, Shiro ; Maruyama, Kei ; Shimizu, Takao ; Shimada, Atsuyoshi. / Excitotoxicity-induced immediate surge in hippocampal prostanoid production has latent effects that promote chronic progressive neuronal death. In: Prostaglandins Leukotrienes and Essential Fatty Acids. 2013 ; Vol. 88, No. 5. pp. 373-381.
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author = "Keisuke Yoshikawa and Yoshihiro Kita and Ayako Furukawa and Noriko Kawamura and Sanae Hasegawa-Ishii and Yoichi Chiba and Shiro Takei and Kei Maruyama and Takao Shimizu and Atsuyoshi Shimada",
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Yoshikawa, K, Kita, Y, Furukawa, A, Kawamura, N, Hasegawa-Ishii, S, Chiba, Y, Takei, S, Maruyama, K, Shimizu, T & Shimada, A 2013, 'Excitotoxicity-induced immediate surge in hippocampal prostanoid production has latent effects that promote chronic progressive neuronal death', Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 88, no. 5, pp. 373-381. https://doi.org/10.1016/j.plefa.2013.02.007

Excitotoxicity-induced immediate surge in hippocampal prostanoid production has latent effects that promote chronic progressive neuronal death. / Yoshikawa, Keisuke; Kita, Yoshihiro; Furukawa, Ayako; Kawamura, Noriko; Hasegawa-Ishii, Sanae; Chiba, Yoichi; Takei, Shiro; Maruyama, Kei; Shimizu, Takao; Shimada, Atsuyoshi.

In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 88, No. 5, 01.05.2013, p. 373-381.

Research output: Contribution to journalArticle

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AU - Yoshikawa, Keisuke

AU - Kita, Yoshihiro

AU - Furukawa, Ayako

AU - Kawamura, Noriko

AU - Hasegawa-Ishii, Sanae

AU - Chiba, Yoichi

AU - Takei, Shiro

AU - Maruyama, Kei

AU - Shimizu, Takao

AU - Shimada, Atsuyoshi

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