As the clinical use of load bearing implants with direct bone-metal interfaces and large surface areas due to porous coatings becomes more common, the question concerning the amount of metal ion release becomes more important. The present study examines the correlation between the amount of metal in animal excretions and the amount of metal ions to which the animals were exposed by injections of metal salts or corrosion products. These experiments have demonstrated a rapid clearance of metal ions following intramuscular injection of metal ions. The presence of nickel in urine from CoCr corrosion products is of surprise, but is consistant with the results of others. The lack of chromium excretion from stainless steel corrosion products may reflect the fact that corrosion of stainless steel in saline produces chromium as plus 3, whereas the biologically active form, and that produced in protein solutions is with a valence of plus 6.
|Original language||English (US)|
|Title of host publication||Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the Interna|
|Publisher||Soc for Biomaterials|
|Number of pages||1|
|State||Published - 1985|
All Science Journal Classification (ASJC) codes
- Materials Science(all)