Exercise adherence in a randomized trial of exercise on aromatase inhibitor arthralgias in breast cancer survivors: the Hormones and Physical Exercise (HOPE) study

Hannah Arem, Mia Sorkin, Brenda Cartmel, Martha Fiellin, Scott Capozza, Maura Harrigan, Elizabeth Ercolano, Yang Zhou, Tara Sanft, Cary Gross, Kathryn Schmitz, Tuhina Neogi, Dawn Hershman, Jennifer Ligibel, Melinda L. Irwin

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Purpose: Up to 50 % of postmenopausal breast cancer survivors taking aromatase inhibitors (AIs) experience AI-associated arthralgias, or joint pain, which causes many to stop taking AIs and may inhibit exercise, despite known health benefits. We thus evaluated exercise adherence and factors associated with better exercise adherence in breast cancer survivors experiencing AI-induced arthralgia in the (HOPE) year long randomized controlled trial. Methods: We included 61 HOPE women randomized to exercise (150 min/week of moderate-intensity aerobic exercise and twice-weekly supervised strength training). Our main outcomes were aerobic exercise measured with daily activity logs, attendance at supervised exercise sessions, and changes in cardiorespiratory fitness, measured maximal oxygen consumption (VO2max). We examined means and standard deviations (SDs) for exercise adherence by demographic and medical characteristics and used the t test for mean differences. We also examined predictors of adherence using linear regression. Results: On average, at the end of the year long trial, women reported 119 (SD 78) min/week of moderate-intensity aerobic exercise and participated in 70 % of supervised exercise training sessions. After adjustment for other factors that influence adherence, at 6 months postrandomization, only baseline VO2max was associated with higher aerobic exercise levels and at 12 months, only older age predicted better supervised exercise training attendance. Conclusions: Breast cancer survivors taking AIs and experiencing arthralgia are able to initiate and maintain a year long exercise program, regardless of other factors that influence activity levels. Implications for Cancer Survivors: Breast cancer survivors can exercise at levels that have been shown to improve AI-associated arthralgia.

Original languageEnglish (US)
Pages (from-to)654-662
Number of pages9
JournalJournal of Cancer Survivorship
Volume10
Issue number4
DOIs
StatePublished - Aug 1 2016

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Aromatase Inhibitors
Arthralgia
Survivors
Hormones
Exercise
Breast Neoplasms
Resistance Training
Insurance Benefits

All Science Journal Classification (ASJC) codes

  • Oncology
  • Oncology(nursing)

Cite this

Arem, Hannah ; Sorkin, Mia ; Cartmel, Brenda ; Fiellin, Martha ; Capozza, Scott ; Harrigan, Maura ; Ercolano, Elizabeth ; Zhou, Yang ; Sanft, Tara ; Gross, Cary ; Schmitz, Kathryn ; Neogi, Tuhina ; Hershman, Dawn ; Ligibel, Jennifer ; Irwin, Melinda L. / Exercise adherence in a randomized trial of exercise on aromatase inhibitor arthralgias in breast cancer survivors : the Hormones and Physical Exercise (HOPE) study. In: Journal of Cancer Survivorship. 2016 ; Vol. 10, No. 4. pp. 654-662.
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title = "Exercise adherence in a randomized trial of exercise on aromatase inhibitor arthralgias in breast cancer survivors: the Hormones and Physical Exercise (HOPE) study",
abstract = "Purpose: Up to 50 {\%} of postmenopausal breast cancer survivors taking aromatase inhibitors (AIs) experience AI-associated arthralgias, or joint pain, which causes many to stop taking AIs and may inhibit exercise, despite known health benefits. We thus evaluated exercise adherence and factors associated with better exercise adherence in breast cancer survivors experiencing AI-induced arthralgia in the (HOPE) year long randomized controlled trial. Methods: We included 61 HOPE women randomized to exercise (150 min/week of moderate-intensity aerobic exercise and twice-weekly supervised strength training). Our main outcomes were aerobic exercise measured with daily activity logs, attendance at supervised exercise sessions, and changes in cardiorespiratory fitness, measured maximal oxygen consumption (VO2max). We examined means and standard deviations (SDs) for exercise adherence by demographic and medical characteristics and used the t test for mean differences. We also examined predictors of adherence using linear regression. Results: On average, at the end of the year long trial, women reported 119 (SD 78) min/week of moderate-intensity aerobic exercise and participated in 70 {\%} of supervised exercise training sessions. After adjustment for other factors that influence adherence, at 6 months postrandomization, only baseline VO2max was associated with higher aerobic exercise levels and at 12 months, only older age predicted better supervised exercise training attendance. Conclusions: Breast cancer survivors taking AIs and experiencing arthralgia are able to initiate and maintain a year long exercise program, regardless of other factors that influence activity levels. Implications for Cancer Survivors: Breast cancer survivors can exercise at levels that have been shown to improve AI-associated arthralgia.",
author = "Hannah Arem and Mia Sorkin and Brenda Cartmel and Martha Fiellin and Scott Capozza and Maura Harrigan and Elizabeth Ercolano and Yang Zhou and Tara Sanft and Cary Gross and Kathryn Schmitz and Tuhina Neogi and Dawn Hershman and Jennifer Ligibel and Irwin, {Melinda L.}",
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Arem, H, Sorkin, M, Cartmel, B, Fiellin, M, Capozza, S, Harrigan, M, Ercolano, E, Zhou, Y, Sanft, T, Gross, C, Schmitz, K, Neogi, T, Hershman, D, Ligibel, J & Irwin, ML 2016, 'Exercise adherence in a randomized trial of exercise on aromatase inhibitor arthralgias in breast cancer survivors: the Hormones and Physical Exercise (HOPE) study', Journal of Cancer Survivorship, vol. 10, no. 4, pp. 654-662. https://doi.org/10.1007/s11764-015-0511-6

Exercise adherence in a randomized trial of exercise on aromatase inhibitor arthralgias in breast cancer survivors : the Hormones and Physical Exercise (HOPE) study. / Arem, Hannah; Sorkin, Mia; Cartmel, Brenda; Fiellin, Martha; Capozza, Scott; Harrigan, Maura; Ercolano, Elizabeth; Zhou, Yang; Sanft, Tara; Gross, Cary; Schmitz, Kathryn; Neogi, Tuhina; Hershman, Dawn; Ligibel, Jennifer; Irwin, Melinda L.

In: Journal of Cancer Survivorship, Vol. 10, No. 4, 01.08.2016, p. 654-662.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Exercise adherence in a randomized trial of exercise on aromatase inhibitor arthralgias in breast cancer survivors

T2 - the Hormones and Physical Exercise (HOPE) study

AU - Arem, Hannah

AU - Sorkin, Mia

AU - Cartmel, Brenda

AU - Fiellin, Martha

AU - Capozza, Scott

AU - Harrigan, Maura

AU - Ercolano, Elizabeth

AU - Zhou, Yang

AU - Sanft, Tara

AU - Gross, Cary

AU - Schmitz, Kathryn

AU - Neogi, Tuhina

AU - Hershman, Dawn

AU - Ligibel, Jennifer

AU - Irwin, Melinda L.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Purpose: Up to 50 % of postmenopausal breast cancer survivors taking aromatase inhibitors (AIs) experience AI-associated arthralgias, or joint pain, which causes many to stop taking AIs and may inhibit exercise, despite known health benefits. We thus evaluated exercise adherence and factors associated with better exercise adherence in breast cancer survivors experiencing AI-induced arthralgia in the (HOPE) year long randomized controlled trial. Methods: We included 61 HOPE women randomized to exercise (150 min/week of moderate-intensity aerobic exercise and twice-weekly supervised strength training). Our main outcomes were aerobic exercise measured with daily activity logs, attendance at supervised exercise sessions, and changes in cardiorespiratory fitness, measured maximal oxygen consumption (VO2max). We examined means and standard deviations (SDs) for exercise adherence by demographic and medical characteristics and used the t test for mean differences. We also examined predictors of adherence using linear regression. Results: On average, at the end of the year long trial, women reported 119 (SD 78) min/week of moderate-intensity aerobic exercise and participated in 70 % of supervised exercise training sessions. After adjustment for other factors that influence adherence, at 6 months postrandomization, only baseline VO2max was associated with higher aerobic exercise levels and at 12 months, only older age predicted better supervised exercise training attendance. Conclusions: Breast cancer survivors taking AIs and experiencing arthralgia are able to initiate and maintain a year long exercise program, regardless of other factors that influence activity levels. Implications for Cancer Survivors: Breast cancer survivors can exercise at levels that have been shown to improve AI-associated arthralgia.

AB - Purpose: Up to 50 % of postmenopausal breast cancer survivors taking aromatase inhibitors (AIs) experience AI-associated arthralgias, or joint pain, which causes many to stop taking AIs and may inhibit exercise, despite known health benefits. We thus evaluated exercise adherence and factors associated with better exercise adherence in breast cancer survivors experiencing AI-induced arthralgia in the (HOPE) year long randomized controlled trial. Methods: We included 61 HOPE women randomized to exercise (150 min/week of moderate-intensity aerobic exercise and twice-weekly supervised strength training). Our main outcomes were aerobic exercise measured with daily activity logs, attendance at supervised exercise sessions, and changes in cardiorespiratory fitness, measured maximal oxygen consumption (VO2max). We examined means and standard deviations (SDs) for exercise adherence by demographic and medical characteristics and used the t test for mean differences. We also examined predictors of adherence using linear regression. Results: On average, at the end of the year long trial, women reported 119 (SD 78) min/week of moderate-intensity aerobic exercise and participated in 70 % of supervised exercise training sessions. After adjustment for other factors that influence adherence, at 6 months postrandomization, only baseline VO2max was associated with higher aerobic exercise levels and at 12 months, only older age predicted better supervised exercise training attendance. Conclusions: Breast cancer survivors taking AIs and experiencing arthralgia are able to initiate and maintain a year long exercise program, regardless of other factors that influence activity levels. Implications for Cancer Survivors: Breast cancer survivors can exercise at levels that have been shown to improve AI-associated arthralgia.

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