Exercise enhances vaccine-induced antigen-specific T cell responses

Connie J. Rogers; David A. Zaharoff; Kenneth W. Hance; Susan N. Perkins; Stephen D. Hursting; Jeffrey Schlom; John W. Greiner

doi:10.1016/j.vaccine.2008.07.081

Exercise enhances vaccine-induced antigen-specific T cell responses

Connie J. Rogers, David A. Zaharoff, Kenneth W. Hance, Susan N. Perkins, Stephen D. Hursting, Jeffrey Schlom, John W. Greiner

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Regular moderate exercise has been proposed to enhance immune function, but its effects on immunity and their consequences have not been well studied. Mice without (AL) or with access (AL + EX) to voluntary running wheels were vaccinated with a model antigen (ovalbumin (OVA)) via intranasal or subcutaneous routes to target the mucosal and systemic immune compartments, respectively. EX enhanced OVA-specific CD4⁺ T cell cytokine production and proliferation in all lymphoid organs examined without changes in cell distribution in any organ. These results suggest that coupling moderate exercise with vaccination may enhance vaccine efficacy for the prevention and/or therapy of numerous diseases.

Original language	English (US)
Pages (from-to)	5407-5415
Number of pages	9
Journal	Vaccine
Volume	26
Issue number	42
DOIs	https://doi.org/10.1016/j.vaccine.2008.07.081
State	Published - Oct 3 2008

All Science Journal Classification (ASJC) codes

Molecular Medicine
Immunology and Microbiology(all)
veterinary(all)
Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vaccine.2008.07.081

Cite this

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title = "Exercise enhances vaccine-induced antigen-specific T cell responses",

abstract = "Regular moderate exercise has been proposed to enhance immune function, but its effects on immunity and their consequences have not been well studied. Mice without (AL) or with access (AL + EX) to voluntary running wheels were vaccinated with a model antigen (ovalbumin (OVA)) via intranasal or subcutaneous routes to target the mucosal and systemic immune compartments, respectively. EX enhanced OVA-specific CD4+ T cell cytokine production and proliferation in all lymphoid organs examined without changes in cell distribution in any organ. These results suggest that coupling moderate exercise with vaccination may enhance vaccine efficacy for the prevention and/or therapy of numerous diseases.",

author = "Rogers, {Connie J.} and Zaharoff, {David A.} and Hance, {Kenneth W.} and Perkins, {Susan N.} and Hursting, {Stephen D.} and Jeffrey Schlom and Greiner, {John W.}",

note = "Funding Information: This research was supported in part by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research, and by the National Cancer Institute Cancer Prevention Fellowship Program. This work was also supported by funding to S. Hursting from NIEHS # P30 ES007784 and the Breast Cancer Research Foundation. ",

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doi = "10.1016/j.vaccine.2008.07.081",

language = "English (US)",

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pages = "5407--5415",

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T1 - Exercise enhances vaccine-induced antigen-specific T cell responses

AU - Rogers, Connie J.

AU - Zaharoff, David A.

AU - Hance, Kenneth W.

AU - Perkins, Susan N.

AU - Hursting, Stephen D.

AU - Schlom, Jeffrey

AU - Greiner, John W.

N1 - Funding Information: This research was supported in part by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research, and by the National Cancer Institute Cancer Prevention Fellowship Program. This work was also supported by funding to S. Hursting from NIEHS # P30 ES007784 and the Breast Cancer Research Foundation.

PY - 2008/10/3

Y1 - 2008/10/3

N2 - Regular moderate exercise has been proposed to enhance immune function, but its effects on immunity and their consequences have not been well studied. Mice without (AL) or with access (AL + EX) to voluntary running wheels were vaccinated with a model antigen (ovalbumin (OVA)) via intranasal or subcutaneous routes to target the mucosal and systemic immune compartments, respectively. EX enhanced OVA-specific CD4+ T cell cytokine production and proliferation in all lymphoid organs examined without changes in cell distribution in any organ. These results suggest that coupling moderate exercise with vaccination may enhance vaccine efficacy for the prevention and/or therapy of numerous diseases.

AB - Regular moderate exercise has been proposed to enhance immune function, but its effects on immunity and their consequences have not been well studied. Mice without (AL) or with access (AL + EX) to voluntary running wheels were vaccinated with a model antigen (ovalbumin (OVA)) via intranasal or subcutaneous routes to target the mucosal and systemic immune compartments, respectively. EX enhanced OVA-specific CD4+ T cell cytokine production and proliferation in all lymphoid organs examined without changes in cell distribution in any organ. These results suggest that coupling moderate exercise with vaccination may enhance vaccine efficacy for the prevention and/or therapy of numerous diseases.

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JO - Vaccine

JF - Vaccine

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ER -

Exercise enhances vaccine-induced antigen-specific T cell responses

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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