Exercise enhances vaccine-induced antigen-specific T cell responses

Connie Jo Rogers, David A. Zaharoff, Kenneth W. Hance, Susan N. Perkins, Stephen D. Hursting, Jeffrey Schlom, John W. Greiner

Research output: Contribution to journalArticle

22 Scopus citations


Regular moderate exercise has been proposed to enhance immune function, but its effects on immunity and their consequences have not been well studied. Mice without (AL) or with access (AL + EX) to voluntary running wheels were vaccinated with a model antigen (ovalbumin (OVA)) via intranasal or subcutaneous routes to target the mucosal and systemic immune compartments, respectively. EX enhanced OVA-specific CD4+ T cell cytokine production and proliferation in all lymphoid organs examined without changes in cell distribution in any organ. These results suggest that coupling moderate exercise with vaccination may enhance vaccine efficacy for the prevention and/or therapy of numerous diseases.

Original languageEnglish (US)
Pages (from-to)5407-5415
Number of pages9
Issue number42
Publication statusPublished - Oct 3 2008


All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Rogers, C. J., Zaharoff, D. A., Hance, K. W., Perkins, S. N., Hursting, S. D., Schlom, J., & Greiner, J. W. (2008). Exercise enhances vaccine-induced antigen-specific T cell responses. Vaccine, 26(42), 5407-5415. https://doi.org/10.1016/j.vaccine.2008.07.081