Exercise-induced dose-response alterations in adiponectin and leptin levels are dependent on body fat changes in women at risk for breast cancer

Kathleen Sturgeon, Laura Digiovanni, Jerene Good, Domenick Salvatore, Desiré Fenderson, Susan Domchek, Jill Stopfer, Mary Lou Galantino, Cathy Bryan, Wei Ting Hwang, Kathryn Schmitz

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Dysregulation of adipokines, such as adiponectin and leptin, is associated with a variety of chronic diseases, including cancer. Physical activity protects against breast cancer and one of the mechanisms which may underlie this association is exercise-induced changes in adipokine levels. The WISER Sister Trial was a three-armed randomized controlled trial in premenopausal women (n = 137) with an elevated risk for breast cancer. Methods: A 5-menstrual-cycle-long dosed aerobic exercise intervention compared low-dose exercise (150 min/wk; n = 44) or high-dose exercise (300 min/wk; n = 48) with a control group asked to maintain usual activity levels (n = 45). Exercise intensity progressed to and was maintained at 70% to 80% of age predicted heart rate max. Body composition and adipokine levels were measured at baseline and follow-up. Results: We observed significant linear trends for increased fitness capacity (Δ%:-2.0% control, 10.1% low dose, 13.1% high dose), decreased fat tissue-to-total tissue mass (Δ%: 0.7% control, -2.9% low dose, -3.7% high dose), increased body fat adjusted adiponectin (Δ%: -0.6% control, 0.6% low dose, 0.9% high dose), and decreased body fat adjusted leptin (Δ%: 0.7% control, -8.2% low dose, -10.2% high dose). Conclusions: In this randomized clinical trial of premenopausal women at risk for breast cancer, we demonstrate a dose-response effect of exercise on adiponectin and leptin and that dose response is dependent on changes in body fat. Impact: Improved adipokine levels, achieved by aerobic exercise training-induced decreases in body fat, may decrease breast cancer risk for high-risk premenopausal women.

Original languageEnglish (US)
Pages (from-to)1195-1200
Number of pages6
JournalCancer Epidemiology Biomarkers and Prevention
Volume25
Issue number8
DOIs
StatePublished - Aug 2016

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Adiponectin
Leptin
Adipose Tissue
Exercise
Breast Neoplasms
Adipokines
Randomized Controlled Trials
Menstrual Cycle
Body Composition
Siblings
Chronic Disease
Heart Rate
Fats
Control Groups

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

Cite this

Sturgeon, Kathleen ; Digiovanni, Laura ; Good, Jerene ; Salvatore, Domenick ; Fenderson, Desiré ; Domchek, Susan ; Stopfer, Jill ; Galantino, Mary Lou ; Bryan, Cathy ; Hwang, Wei Ting ; Schmitz, Kathryn. / Exercise-induced dose-response alterations in adiponectin and leptin levels are dependent on body fat changes in women at risk for breast cancer. In: Cancer Epidemiology Biomarkers and Prevention. 2016 ; Vol. 25, No. 8. pp. 1195-1200.
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title = "Exercise-induced dose-response alterations in adiponectin and leptin levels are dependent on body fat changes in women at risk for breast cancer",
abstract = "Background: Dysregulation of adipokines, such as adiponectin and leptin, is associated with a variety of chronic diseases, including cancer. Physical activity protects against breast cancer and one of the mechanisms which may underlie this association is exercise-induced changes in adipokine levels. The WISER Sister Trial was a three-armed randomized controlled trial in premenopausal women (n = 137) with an elevated risk for breast cancer. Methods: A 5-menstrual-cycle-long dosed aerobic exercise intervention compared low-dose exercise (150 min/wk; n = 44) or high-dose exercise (300 min/wk; n = 48) with a control group asked to maintain usual activity levels (n = 45). Exercise intensity progressed to and was maintained at 70{\%} to 80{\%} of age predicted heart rate max. Body composition and adipokine levels were measured at baseline and follow-up. Results: We observed significant linear trends for increased fitness capacity (Δ{\%}:-2.0{\%} control, 10.1{\%} low dose, 13.1{\%} high dose), decreased fat tissue-to-total tissue mass (Δ{\%}: 0.7{\%} control, -2.9{\%} low dose, -3.7{\%} high dose), increased body fat adjusted adiponectin (Δ{\%}: -0.6{\%} control, 0.6{\%} low dose, 0.9{\%} high dose), and decreased body fat adjusted leptin (Δ{\%}: 0.7{\%} control, -8.2{\%} low dose, -10.2{\%} high dose). Conclusions: In this randomized clinical trial of premenopausal women at risk for breast cancer, we demonstrate a dose-response effect of exercise on adiponectin and leptin and that dose response is dependent on changes in body fat. Impact: Improved adipokine levels, achieved by aerobic exercise training-induced decreases in body fat, may decrease breast cancer risk for high-risk premenopausal women.",
author = "Kathleen Sturgeon and Laura Digiovanni and Jerene Good and Domenick Salvatore and Desir{\'e} Fenderson and Susan Domchek and Jill Stopfer and Galantino, {Mary Lou} and Cathy Bryan and Hwang, {Wei Ting} and Kathryn Schmitz",
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Exercise-induced dose-response alterations in adiponectin and leptin levels are dependent on body fat changes in women at risk for breast cancer. / Sturgeon, Kathleen; Digiovanni, Laura; Good, Jerene; Salvatore, Domenick; Fenderson, Desiré; Domchek, Susan; Stopfer, Jill; Galantino, Mary Lou; Bryan, Cathy; Hwang, Wei Ting; Schmitz, Kathryn.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 25, No. 8, 08.2016, p. 1195-1200.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Exercise-induced dose-response alterations in adiponectin and leptin levels are dependent on body fat changes in women at risk for breast cancer

AU - Sturgeon, Kathleen

AU - Digiovanni, Laura

AU - Good, Jerene

AU - Salvatore, Domenick

AU - Fenderson, Desiré

AU - Domchek, Susan

AU - Stopfer, Jill

AU - Galantino, Mary Lou

AU - Bryan, Cathy

AU - Hwang, Wei Ting

AU - Schmitz, Kathryn

PY - 2016/8

Y1 - 2016/8

N2 - Background: Dysregulation of adipokines, such as adiponectin and leptin, is associated with a variety of chronic diseases, including cancer. Physical activity protects against breast cancer and one of the mechanisms which may underlie this association is exercise-induced changes in adipokine levels. The WISER Sister Trial was a three-armed randomized controlled trial in premenopausal women (n = 137) with an elevated risk for breast cancer. Methods: A 5-menstrual-cycle-long dosed aerobic exercise intervention compared low-dose exercise (150 min/wk; n = 44) or high-dose exercise (300 min/wk; n = 48) with a control group asked to maintain usual activity levels (n = 45). Exercise intensity progressed to and was maintained at 70% to 80% of age predicted heart rate max. Body composition and adipokine levels were measured at baseline and follow-up. Results: We observed significant linear trends for increased fitness capacity (Δ%:-2.0% control, 10.1% low dose, 13.1% high dose), decreased fat tissue-to-total tissue mass (Δ%: 0.7% control, -2.9% low dose, -3.7% high dose), increased body fat adjusted adiponectin (Δ%: -0.6% control, 0.6% low dose, 0.9% high dose), and decreased body fat adjusted leptin (Δ%: 0.7% control, -8.2% low dose, -10.2% high dose). Conclusions: In this randomized clinical trial of premenopausal women at risk for breast cancer, we demonstrate a dose-response effect of exercise on adiponectin and leptin and that dose response is dependent on changes in body fat. Impact: Improved adipokine levels, achieved by aerobic exercise training-induced decreases in body fat, may decrease breast cancer risk for high-risk premenopausal women.

AB - Background: Dysregulation of adipokines, such as adiponectin and leptin, is associated with a variety of chronic diseases, including cancer. Physical activity protects against breast cancer and one of the mechanisms which may underlie this association is exercise-induced changes in adipokine levels. The WISER Sister Trial was a three-armed randomized controlled trial in premenopausal women (n = 137) with an elevated risk for breast cancer. Methods: A 5-menstrual-cycle-long dosed aerobic exercise intervention compared low-dose exercise (150 min/wk; n = 44) or high-dose exercise (300 min/wk; n = 48) with a control group asked to maintain usual activity levels (n = 45). Exercise intensity progressed to and was maintained at 70% to 80% of age predicted heart rate max. Body composition and adipokine levels were measured at baseline and follow-up. Results: We observed significant linear trends for increased fitness capacity (Δ%:-2.0% control, 10.1% low dose, 13.1% high dose), decreased fat tissue-to-total tissue mass (Δ%: 0.7% control, -2.9% low dose, -3.7% high dose), increased body fat adjusted adiponectin (Δ%: -0.6% control, 0.6% low dose, 0.9% high dose), and decreased body fat adjusted leptin (Δ%: 0.7% control, -8.2% low dose, -10.2% high dose). Conclusions: In this randomized clinical trial of premenopausal women at risk for breast cancer, we demonstrate a dose-response effect of exercise on adiponectin and leptin and that dose response is dependent on changes in body fat. Impact: Improved adipokine levels, achieved by aerobic exercise training-induced decreases in body fat, may decrease breast cancer risk for high-risk premenopausal women.

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