Abstract
Leg exercise hemodynamics during single-leg knee extensions were compared among healthy groups of early perimenopausal (n = 15), late perimenopausal (n = 12), and early postmenopausal (n = 11) women. Femoral blood flow (FBF) and vascular conductance (FVC) at rest and during very light work rates (0 and 5 W) were similar among all three menopause stage groups. Vascular responses at 10 W (FBF) and 20 W (FBF and FVC) were significantly higher (P < 0.05) in early perimenopausal compared with late perimenopausal women. At 15 and 25 W, FBF and FVC were similar between late perimenopausal and early postmenopausal groups but higher (P < 0.05) in early perimenopausal women as compared with the other two menopausal groups. In the combined sample of all three menopause stage groups, follicle-stimulating hormone was significantly correlated with vascular conductance during submaximal (15 W) exercise (R = -0.56, P < 0.001), even after adjustment for age, fitness, LDL cholesterol, and abdominal fat (R = -0.46, P = 0.005). Collectively, these findings suggest that in middle-aged women, there is an association between menopause stage and leg vascular responsiveness during exercise.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 418-424 |
| Number of pages | 7 |
| Journal | Applied Physiology, Nutrition and Metabolism |
| Volume | 37 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 1 2012 |
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All Science Journal Classification (ASJC) codes
- Endocrinology, Diabetes and Metabolism
- Physiology
- Nutrition and Dietetics
- Physiology (medical)
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Exercise-induced vasodilation is associated with menopause stage in healthy middle-aged women. / Moore, David; Gonzales, Joaquin U.; Tucker, Steven H.; Elavsky, Steriani; Proctor, David Nathan.
In: Applied Physiology, Nutrition and Metabolism, Vol. 37, No. 3, 01.06.2012, p. 418-424.Research output: Contribution to journal › Article
TY - JOUR
T1 - Exercise-induced vasodilation is associated with menopause stage in healthy middle-aged women
AU - Moore, David
AU - Gonzales, Joaquin U.
AU - Tucker, Steven H.
AU - Elavsky, Steriani
AU - Proctor, David Nathan
PY - 2012/6/1
Y1 - 2012/6/1
N2 - Leg exercise hemodynamics during single-leg knee extensions were compared among healthy groups of early perimenopausal (n = 15), late perimenopausal (n = 12), and early postmenopausal (n = 11) women. Femoral blood flow (FBF) and vascular conductance (FVC) at rest and during very light work rates (0 and 5 W) were similar among all three menopause stage groups. Vascular responses at 10 W (FBF) and 20 W (FBF and FVC) were significantly higher (P < 0.05) in early perimenopausal compared with late perimenopausal women. At 15 and 25 W, FBF and FVC were similar between late perimenopausal and early postmenopausal groups but higher (P < 0.05) in early perimenopausal women as compared with the other two menopausal groups. In the combined sample of all three menopause stage groups, follicle-stimulating hormone was significantly correlated with vascular conductance during submaximal (15 W) exercise (R = -0.56, P < 0.001), even after adjustment for age, fitness, LDL cholesterol, and abdominal fat (R = -0.46, P = 0.005). Collectively, these findings suggest that in middle-aged women, there is an association between menopause stage and leg vascular responsiveness during exercise.
AB - Leg exercise hemodynamics during single-leg knee extensions were compared among healthy groups of early perimenopausal (n = 15), late perimenopausal (n = 12), and early postmenopausal (n = 11) women. Femoral blood flow (FBF) and vascular conductance (FVC) at rest and during very light work rates (0 and 5 W) were similar among all three menopause stage groups. Vascular responses at 10 W (FBF) and 20 W (FBF and FVC) were significantly higher (P < 0.05) in early perimenopausal compared with late perimenopausal women. At 15 and 25 W, FBF and FVC were similar between late perimenopausal and early postmenopausal groups but higher (P < 0.05) in early perimenopausal women as compared with the other two menopausal groups. In the combined sample of all three menopause stage groups, follicle-stimulating hormone was significantly correlated with vascular conductance during submaximal (15 W) exercise (R = -0.56, P < 0.001), even after adjustment for age, fitness, LDL cholesterol, and abdominal fat (R = -0.46, P = 0.005). Collectively, these findings suggest that in middle-aged women, there is an association between menopause stage and leg vascular responsiveness during exercise.
UR - http://www.scopus.com/inward/record.url?scp=84860485350&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860485350&partnerID=8YFLogxK
U2 - 10.1139/H2012-015
DO - 10.1139/H2012-015
M3 - Article
C2 - 22486379
AN - SCOPUS:84860485350
VL - 37
SP - 418
EP - 424
JO - Applied Physiology, Nutrition and Metabolism
JF - Applied Physiology, Nutrition and Metabolism
SN - 1715-5312
IS - 3
ER -