Exercise-induced vasodilation is associated with menopause stage in healthy middle-aged women

David Moore, Joaquin U. Gonzales, Steven H. Tucker, Steriani Elavsky, David Nathan Proctor

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Leg exercise hemodynamics during single-leg knee extensions were compared among healthy groups of early perimenopausal (n = 15), late perimenopausal (n = 12), and early postmenopausal (n = 11) women. Femoral blood flow (FBF) and vascular conductance (FVC) at rest and during very light work rates (0 and 5 W) were similar among all three menopause stage groups. Vascular responses at 10 W (FBF) and 20 W (FBF and FVC) were significantly higher (P < 0.05) in early perimenopausal compared with late perimenopausal women. At 15 and 25 W, FBF and FVC were similar between late perimenopausal and early postmenopausal groups but higher (P < 0.05) in early perimenopausal women as compared with the other two menopausal groups. In the combined sample of all three menopause stage groups, follicle-stimulating hormone was significantly correlated with vascular conductance during submaximal (15 W) exercise (R = -0.56, P < 0.001), even after adjustment for age, fitness, LDL cholesterol, and abdominal fat (R = -0.46, P = 0.005). Collectively, these findings suggest that in middle-aged women, there is an association between menopause stage and leg vascular responsiveness during exercise.

Original languageEnglish (US)
Pages (from-to)418-424
Number of pages7
JournalApplied Physiology, Nutrition and Metabolism
Volume37
Issue number3
DOIs
StatePublished - Jun 1 2012

Fingerprint

Menopause
Vasodilation
Blood Vessels
Exercise
Thigh
Leg
Abdominal Fat
Follicle Stimulating Hormone
LDL Cholesterol
Knee
Hemodynamics
Light

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Nutrition and Dietetics
  • Physiology (medical)

Cite this

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title = "Exercise-induced vasodilation is associated with menopause stage in healthy middle-aged women",
abstract = "Leg exercise hemodynamics during single-leg knee extensions were compared among healthy groups of early perimenopausal (n = 15), late perimenopausal (n = 12), and early postmenopausal (n = 11) women. Femoral blood flow (FBF) and vascular conductance (FVC) at rest and during very light work rates (0 and 5 W) were similar among all three menopause stage groups. Vascular responses at 10 W (FBF) and 20 W (FBF and FVC) were significantly higher (P < 0.05) in early perimenopausal compared with late perimenopausal women. At 15 and 25 W, FBF and FVC were similar between late perimenopausal and early postmenopausal groups but higher (P < 0.05) in early perimenopausal women as compared with the other two menopausal groups. In the combined sample of all three menopause stage groups, follicle-stimulating hormone was significantly correlated with vascular conductance during submaximal (15 W) exercise (R = -0.56, P < 0.001), even after adjustment for age, fitness, LDL cholesterol, and abdominal fat (R = -0.46, P = 0.005). Collectively, these findings suggest that in middle-aged women, there is an association between menopause stage and leg vascular responsiveness during exercise.",
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Exercise-induced vasodilation is associated with menopause stage in healthy middle-aged women. / Moore, David; Gonzales, Joaquin U.; Tucker, Steven H.; Elavsky, Steriani; Proctor, David Nathan.

In: Applied Physiology, Nutrition and Metabolism, Vol. 37, No. 3, 01.06.2012, p. 418-424.

Research output: Contribution to journalArticle

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