Expandable and implantable bioelectronic complex for analyzing and regulating real-time activity of the urinary bladder

Tae Min Jang, Joong Hoon Lee, Honglei Zhou, Jaesun Joo, Bong Hee Lim, Huanyu Cheng, Soo Hyun Kim, Il Suk Kang, Kyu Sung Lee, Eunkyoung Park, Suk Won Hwang

Research output: Contribution to journalArticlepeer-review

Abstract

Underactive bladder or detrusor underactivity (DUA), that is, not being able to micturate, has received less attention with little research and remains unknown or limited on pathological causes and treatments as opposed to overactive bladder, although the syndrome may pose a risk of urinary infections or life-threatening kidney damage. Here, we present an integrated expandable electronic and optoelectronic complex that behaves as a single body with the elastic, time-dynamic urinary bladder with substantial volume changes up to ~300%. The system configuration of the electronics validated by the theoretical model allows conformal, seamless integration onto the urinary bladder without a glue or suture, enabling precise monitoring with various electrical components for real-time status and efficient optogenetic manipulation for urination at the desired time. In vivo experiments using diabetic DUA models demonstrate the possibility for practical uses of high-fidelity electronics in clinical trials associated with the bladder and other elastic organs.

Original languageEnglish (US)
Article numbereabc9675
JournalScience Advances
Volume6
Issue number46
DOIs
StatePublished - Nov 11 2020

All Science Journal Classification (ASJC) codes

  • General

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