Expanding knowledge of P3 proteins in the poliovirus lifecycle

Craig Eugene Cameron, Hyung Suk Oh, Ibrahim Moustafa

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

Poliovirus is the most extensively studied member of the order Picornavirales, which contains numerous medical, veterinary and agricultural pathogens. The picornavirus genome encodes a single polyprotein that is divided into three regions: P1, P2 and P3. P3 proteins are known to participate more directly in genome replication, for example by containing the viral RNA-dependent RNA polymerase (RdRp or 3Dpol), among several other proteins and enzymes. We will review recent data that provide new insight into the structure, function and mechanism of P3 proteins and their complexes, which are required for initiation of genome replication. Replication of poliovirus genomes occurs within macromolecular complexes, containing viral RNA, viral proteins and host-cell membranes, collectively referred to as replication complexes. P2 proteins clearly contribute to interactions with the host cell that are required for virus multiplication, including formation of replication complexes. We will discuss recent data that suggest a role for P3 proteins in formation of replication complexes. Among the least understood steps of the poliovirus lifecycle is encapsidation of genomic RNA. We will also describe data that suggest a role for P3 proteins in this step.

Original languageEnglish (US)
Pages (from-to)867-881
Number of pages15
JournalFuture microbiology
Volume5
Issue number6
DOIs
StatePublished - Jun 1 2010

Fingerprint

Poliovirus
Genome
Proteins
Viral RNA
Picornaviridae
Macromolecular Substances
RNA Replicase
Polyproteins
Viral Proteins
Cell Membrane
RNA
Viruses
Enzymes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)

Cite this

Cameron, Craig Eugene ; Suk Oh, Hyung ; Moustafa, Ibrahim. / Expanding knowledge of P3 proteins in the poliovirus lifecycle. In: Future microbiology. 2010 ; Vol. 5, No. 6. pp. 867-881.
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Expanding knowledge of P3 proteins in the poliovirus lifecycle. / Cameron, Craig Eugene; Suk Oh, Hyung; Moustafa, Ibrahim.

In: Future microbiology, Vol. 5, No. 6, 01.06.2010, p. 867-881.

Research output: Contribution to journalReview article

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