Expanding protein universe and its origin from the biological Big Bang

Nikolay V. Dokholyan, Boris Shakhnovich, Eugene I. Shakhnovich

Research output: Contribution to journalArticle

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Abstract

The bottom-up approach to understanding the evolution of organisms is by studying molecular evolution. With the large number of protein structures identified in the past decades, we have discovered peculiar patterns that nature imprints on protein structural space in the course of evolution. In particular, we have discovered that the universe of protein structures is organized hierarchically into a scale-free network. By understanding the cause of these patterns, we attempt to glance at the very origin of life.

Original languageEnglish (US)
Pages (from-to)14132-14136
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume99
Issue number22
DOIs
Publication statusPublished - Oct 29 2002

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