Abstract

Abnormal expansion of hexanucleotide GGGGCC (G 4 C 2 ) in the C9ORF72 gene has been associated with multiple neurodegenerative disorders, with particularly high prevalence in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Repeat expansions of this type have been associated with altered pathology, symptom rate and severity, as well as psychological changes. In this study, we enrolled twenty-five patients with ALS and fifteen neurologically healthy controls in a P300 brain-computer interface (BCI) training procedure. Four of the patients were found to possess an expanded allele, which was associated with a reduction in the quality of evoked potentials that led to reduced performance on the BCI task. Our findings warrant further exploration of the relationship between brain function and G 4 C 2 repeat length. Such a relationship suggests that personalized assessment of suitability of BCI as a communication device in patients with ALS may be feasible.

Original languageEnglish (US)
Article number8875
JournalScientific reports
Volume7
Issue number1
DOIs
StatePublished - Dec 1 2017

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Brain-Computer Interfaces
Amyotrophic Lateral Sclerosis
Evoked Potentials
Neurodegenerative Diseases
Alleles
Communication
Pathology
Psychology
Equipment and Supplies
Brain
Genes

All Science Journal Classification (ASJC) codes

  • General

Cite this

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title = "Expansion of C9ORF72 in amyotrophic lateral sclerosis correlates with brain-computer interface performance",
abstract = "Abnormal expansion of hexanucleotide GGGGCC (G 4 C 2 ) in the C9ORF72 gene has been associated with multiple neurodegenerative disorders, with particularly high prevalence in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Repeat expansions of this type have been associated with altered pathology, symptom rate and severity, as well as psychological changes. In this study, we enrolled twenty-five patients with ALS and fifteen neurologically healthy controls in a P300 brain-computer interface (BCI) training procedure. Four of the patients were found to possess an expanded allele, which was associated with a reduction in the quality of evoked potentials that led to reduced performance on the BCI task. Our findings warrant further exploration of the relationship between brain function and G 4 C 2 repeat length. Such a relationship suggests that personalized assessment of suitability of BCI as a communication device in patients with ALS may be feasible.",
author = "Andrew Geronimo and Sheldon, {Kathryn E.} and Broach, {James R.} and Zachary Simmons and Schiff, {Steven J.}",
year = "2017",
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T1 - Expansion of C9ORF72 in amyotrophic lateral sclerosis correlates with brain-computer interface performance

AU - Geronimo, Andrew

AU - Sheldon, Kathryn E.

AU - Broach, James R.

AU - Simmons, Zachary

AU - Schiff, Steven J.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Abnormal expansion of hexanucleotide GGGGCC (G 4 C 2 ) in the C9ORF72 gene has been associated with multiple neurodegenerative disorders, with particularly high prevalence in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Repeat expansions of this type have been associated with altered pathology, symptom rate and severity, as well as psychological changes. In this study, we enrolled twenty-five patients with ALS and fifteen neurologically healthy controls in a P300 brain-computer interface (BCI) training procedure. Four of the patients were found to possess an expanded allele, which was associated with a reduction in the quality of evoked potentials that led to reduced performance on the BCI task. Our findings warrant further exploration of the relationship between brain function and G 4 C 2 repeat length. Such a relationship suggests that personalized assessment of suitability of BCI as a communication device in patients with ALS may be feasible.

AB - Abnormal expansion of hexanucleotide GGGGCC (G 4 C 2 ) in the C9ORF72 gene has been associated with multiple neurodegenerative disorders, with particularly high prevalence in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Repeat expansions of this type have been associated with altered pathology, symptom rate and severity, as well as psychological changes. In this study, we enrolled twenty-five patients with ALS and fifteen neurologically healthy controls in a P300 brain-computer interface (BCI) training procedure. Four of the patients were found to possess an expanded allele, which was associated with a reduction in the quality of evoked potentials that led to reduced performance on the BCI task. Our findings warrant further exploration of the relationship between brain function and G 4 C 2 repeat length. Such a relationship suggests that personalized assessment of suitability of BCI as a communication device in patients with ALS may be feasible.

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