Expansion of host cellular niche can drive adaptation of a zoonotic malaria parasite to humans

Caeul Lim, Elsa Katrina Hansen, Tiffany M. Desimone, Yovany Moreno, Klara Junker, Amy Bei, Carlo Brugnara, Caroline O. Buckee, Manoj T. Duraisingh

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The macaque malaria parasite Plasmodium knowlesi has recently emerged as an important zoonosis in Southeast Asia. Infections are typically mild but can cause severe disease, achieving parasite densities similar to fatal Plasmodium falciparum infections. Here we show that a primate-adapted P. knowlesi parasite proliferates poorly in human blood due to a strong preference for young red blood cells (RBCs). We establish a continuous in vitro culture system by using human blood enriched for young cells. Mathematical modelling predicts that parasite adaptation for invasion of older RBCs is a likely mechanism leading to high parasite densities in clinical infections. Consistent with this model, we find that P. knowlesi can adapt to invade a wider age range of RBCs, resulting in proliferation in normal human blood. Such cellular niche expansion may increase pathogenesis in humans and will be a key feature to monitor as P. knowlesi emerges in human populations.

Original languageEnglish (US)
Article number1638
JournalNature communications
Volume4
DOIs
StatePublished - Apr 9 2013

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parasites
Plasmodium knowlesi
Zoonoses
Malaria
Parasites
Blood
erythrocytes
infectious diseases
expansion
blood
Erythrocytes
Southeast Asia
primates
pathogenesis
Southeastern Asia
Macaca
Plasmodium falciparum
Infection
Primates
Cells

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Lim, Caeul ; Hansen, Elsa Katrina ; Desimone, Tiffany M. ; Moreno, Yovany ; Junker, Klara ; Bei, Amy ; Brugnara, Carlo ; Buckee, Caroline O. ; Duraisingh, Manoj T. / Expansion of host cellular niche can drive adaptation of a zoonotic malaria parasite to humans. In: Nature communications. 2013 ; Vol. 4.
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Lim, C, Hansen, EK, Desimone, TM, Moreno, Y, Junker, K, Bei, A, Brugnara, C, Buckee, CO & Duraisingh, MT 2013, 'Expansion of host cellular niche can drive adaptation of a zoonotic malaria parasite to humans', Nature communications, vol. 4, 1638. https://doi.org/10.1038/ncomms2612

Expansion of host cellular niche can drive adaptation of a zoonotic malaria parasite to humans. / Lim, Caeul; Hansen, Elsa Katrina; Desimone, Tiffany M.; Moreno, Yovany; Junker, Klara; Bei, Amy; Brugnara, Carlo; Buckee, Caroline O.; Duraisingh, Manoj T.

In: Nature communications, Vol. 4, 1638, 09.04.2013.

Research output: Contribution to journalArticle

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AU - Lim, Caeul

AU - Hansen, Elsa Katrina

AU - Desimone, Tiffany M.

AU - Moreno, Yovany

AU - Junker, Klara

AU - Bei, Amy

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AU - Buckee, Caroline O.

AU - Duraisingh, Manoj T.

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