Expansion of natural (NK1+) T cells that express αβ T cell receptors in transporters associated with antigen presentation-1 null and thymus leukemia antigen positive mice

Sebastian Joyce, Izumi Negishi, Alina Boesteanu, A. Dharshan DeSilva, Padmanee Sharma, Michael J. Chorney, Dennis Y. Loh, Luc Van Kaer

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Thymic selection of natural killer-11 natural cells that express αβ T cell receptors requires a conserved β2-microglobulin-associated molecule, presumably CD1d, displayed by CD4+8+ thymocytes. Here we demonstrate that positive selection of natural T cells occurs independent of transporters associated with antigen presentation-1 (TAP-1) function. Moreover, natural T cells in TAP-1(0/0) mice are numerically expanded. Several H-2 class Ib molecules function in a TAP-independent manner, suggesting that if expressed in TAP-1(0/0) thymocytes, they could play a role in natural T cell development. Of these class Ib molecules, H-2TL is expressed by TAP-1(0/0) thymocytes. Moreover, we find that thymi of TL+ mice congenic or transgenic for H-2T18 also have a numerically expanded natural T cell repertoire compared with TL+ mice. This expansion, as in TAP-1(0/0) thymi, is evident in each of the limited T cell receptor Vβ chains expressed by natural T cells, suggesting tat TL and CD1d impact similar repertoires. Thus TL, in addition to CD1d, plays a role in natural T cell development.

Original languageEnglish (US)
Pages (from-to)1579-1584
Number of pages6
JournalJournal of Experimental Medicine
Volume184
Issue number4
DOIs
StatePublished - Oct 1 1996

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Antigen Presentation
T-Cell Antigen Receptor
T-Lymphocytes
Thymocytes
Genetic Selection
Thymus Gland
CD1d Antigen
Congenic Mice
Natural Killer Cells
Transgenic Mice
thymus-leukemia antigens

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Joyce, Sebastian ; Negishi, Izumi ; Boesteanu, Alina ; DeSilva, A. Dharshan ; Sharma, Padmanee ; Chorney, Michael J. ; Loh, Dennis Y. ; Van Kaer, Luc. / Expansion of natural (NK1+) T cells that express αβ T cell receptors in transporters associated with antigen presentation-1 null and thymus leukemia antigen positive mice. In: Journal of Experimental Medicine. 1996 ; Vol. 184, No. 4. pp. 1579-1584.
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Expansion of natural (NK1+) T cells that express αβ T cell receptors in transporters associated with antigen presentation-1 null and thymus leukemia antigen positive mice. / Joyce, Sebastian; Negishi, Izumi; Boesteanu, Alina; DeSilva, A. Dharshan; Sharma, Padmanee; Chorney, Michael J.; Loh, Dennis Y.; Van Kaer, Luc.

In: Journal of Experimental Medicine, Vol. 184, No. 4, 01.10.1996, p. 1579-1584.

Research output: Contribution to journalArticle

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