Experimental and computational investigation of altered mechanical properties in myocardium after hydrogel injection

Elena Tous Kichula, Hua Wang, Shauna M. Dorsey, Spencer E. Szczesny, Dawn M. Elliott, Jason A. Burdick, Jonathan F. Wenk

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The material properties of myocardium are an important determinant of global left ventricular function. Myocardial infarction results in a series of maladaptive geometric alterations which lead to increased stress and risk of heart failure. In vivo studies have demonstrated that material injection can mitigate these changes. More importantly, the material properties of these injectates can be tuned to minimize wall thinning and ventricular dilation. The current investigation combines experimental data and finite element modeling to correlate how injectate mechanics and volume influence myocardial wall stress. Experimentally, mechanics were characterized with biaxial testing and injected hydrogel volumes were measured with magnetic resonance imaging. Injection of hyaluronic acid hydrogel increased the stiffness of the myocardium/hydrogel composite region in an anisotropic manner, significantly increasing the modulus in the longitudinal direction compared to control myocardium. Increased stiffness, in combination with increased volume from hydrogel injection, reduced the global average fiber stress by ~14% and the transmural average by ~26% in the simulations. Additionally, stiffening in an anisotropic manner enhanced the influence of hydrogel treatment in decreasing stress. Overall, this work provides insight on how injectable biomaterials can be used to attenuate wall stress and provides tools to further optimize material properties for therapeutic applications.

Original languageEnglish (US)
Pages (from-to)1546-1556
Number of pages11
JournalAnnals of Biomedical Engineering
Volume42
Issue number7
DOIs
StatePublished - Jul 2014

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Hydrogels
Mechanical properties
Materials properties
Mechanics
Stiffness
Hyaluronic acid
Magnetic resonance
Biomaterials
Imaging techniques
Fibers
Composite materials
Testing

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

Cite this

Kichula, Elena Tous ; Wang, Hua ; Dorsey, Shauna M. ; Szczesny, Spencer E. ; Elliott, Dawn M. ; Burdick, Jason A. ; Wenk, Jonathan F. / Experimental and computational investigation of altered mechanical properties in myocardium after hydrogel injection. In: Annals of Biomedical Engineering. 2014 ; Vol. 42, No. 7. pp. 1546-1556.
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Experimental and computational investigation of altered mechanical properties in myocardium after hydrogel injection. / Kichula, Elena Tous; Wang, Hua; Dorsey, Shauna M.; Szczesny, Spencer E.; Elliott, Dawn M.; Burdick, Jason A.; Wenk, Jonathan F.

In: Annals of Biomedical Engineering, Vol. 42, No. 7, 07.2014, p. 1546-1556.

Research output: Contribution to journalArticle

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