Experimental Pseudomonas pneumonia in leukopenic dogs: comparison of therapy with antibiotics and granulocyte transfusions

D. C. Dale, Herbert Reynolds, J. E. Pennington, R. J. Elin, G. P. Herzig

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Pseudomonas aeruginosa pneumonia was produced in dogs with radiation induced leukopenia to study the comparative efficacy of several different therapies. In a randomized control trial, five treatment regimens were compared: no antibiotics or granulocytes (controls), gentamicin (5 mg/kg/day), carbenicillin (500 mg/kg/day), gentamicin and carbenicillin (same dosages), and daily granulocyte transfusions (minimum 5 x 10 9 cells/day) plus gentamicin (5 mg/kg/day). The most effective therapy was gentamicin plus granulocyte transfusions. Gentamicin alone was not significantly better than no specific therapy. Carbenicillin with or without gentamicin gave intermediate results. This study further supports the utility of granulocyte replacement therapy of infections in severely granulocytopenic subjects. The results also indicate that the relative value of granulocyte transfusions depends upon the specific antibiotic regimen with which these transfusions are compared.

Original languageEnglish (US)
Pages (from-to)869-876
Number of pages8
JournalBlood
Volume47
Issue number5
StatePublished - Dec 1 1976

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Pseudomonas
Gentamicins
Granulocytes
Pneumonia
Dogs
Anti-Bacterial Agents
Carbenicillin
Therapeutics
Leukopenia
Pseudomonas aeruginosa
Radiation
Infection

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Dale, D. C., Reynolds, H., Pennington, J. E., Elin, R. J., & Herzig, G. P. (1976). Experimental Pseudomonas pneumonia in leukopenic dogs: comparison of therapy with antibiotics and granulocyte transfusions. Blood, 47(5), 869-876.
Dale, D. C. ; Reynolds, Herbert ; Pennington, J. E. ; Elin, R. J. ; Herzig, G. P. / Experimental Pseudomonas pneumonia in leukopenic dogs : comparison of therapy with antibiotics and granulocyte transfusions. In: Blood. 1976 ; Vol. 47, No. 5. pp. 869-876.
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Dale, DC, Reynolds, H, Pennington, JE, Elin, RJ & Herzig, GP 1976, 'Experimental Pseudomonas pneumonia in leukopenic dogs: comparison of therapy with antibiotics and granulocyte transfusions', Blood, vol. 47, no. 5, pp. 869-876.

Experimental Pseudomonas pneumonia in leukopenic dogs : comparison of therapy with antibiotics and granulocyte transfusions. / Dale, D. C.; Reynolds, Herbert; Pennington, J. E.; Elin, R. J.; Herzig, G. P.

In: Blood, Vol. 47, No. 5, 01.12.1976, p. 869-876.

Research output: Contribution to journalArticle

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Dale DC, Reynolds H, Pennington JE, Elin RJ, Herzig GP. Experimental Pseudomonas pneumonia in leukopenic dogs: comparison of therapy with antibiotics and granulocyte transfusions. Blood. 1976 Dec 1;47(5):869-876.