Expert committee recommendations for acne management

Research output: Contribution to journalReview article

89 Citations (Scopus)

Abstract

In 2003, an international committee of physicians and researchers in the field of acne, working together as the Global Alliance to Improve Outcomes in Acne, developed consensus guidelines for the treatment of acne. These guidelines were evidence based when possible but also included the extensive clinical experience of this group of international dermatologists. As a result of the evaluation of available data and the experience, significant changes occurred in the management routines for acne. The greatest change arose on the basis of improved understanding of acne pathophysiology. The recommendation now is that acne treatments should be combined to target as many pathogenic factors as possible. • A topical retinoid should be the foundation of treatment for most patients with acne, because retinoids target the microcomedo, the precursor to all acne lesions. Retinoids also are comedolytic and have intrinsic antiinflammatory effects, thus targeting 2 pathogenic factors in acne. • Combining a topical retinoid with an antimicrobial agent targets 3 pathogenic factors, and clinical trials have shown that comination therapy results in significantly faster and greater clearing as opposed to antimicrobial therapy alone. • Oral antibiotics should be used only in moderate-to-severe acne, should not be used as monotherapy, and should be discontinued as soon as possible (usually within 8-12 weeks). • Because of their effect on the microcomedo, topical retinoids also are recommended as an important facet of maintenance therapy.

Original languageEnglish (US)
Pages (from-to)1188-1199
Number of pages12
JournalPediatrics
Volume118
Issue number3
DOIs
StatePublished - Sep 1 2006

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Acne Vulgaris
Retinoids
Therapeutics
Guidelines
Anti-Infective Agents
Anti-Inflammatory Agents
Research Personnel
Clinical Trials
Anti-Bacterial Agents
Physicians

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

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title = "Expert committee recommendations for acne management",
abstract = "In 2003, an international committee of physicians and researchers in the field of acne, working together as the Global Alliance to Improve Outcomes in Acne, developed consensus guidelines for the treatment of acne. These guidelines were evidence based when possible but also included the extensive clinical experience of this group of international dermatologists. As a result of the evaluation of available data and the experience, significant changes occurred in the management routines for acne. The greatest change arose on the basis of improved understanding of acne pathophysiology. The recommendation now is that acne treatments should be combined to target as many pathogenic factors as possible. • A topical retinoid should be the foundation of treatment for most patients with acne, because retinoids target the microcomedo, the precursor to all acne lesions. Retinoids also are comedolytic and have intrinsic antiinflammatory effects, thus targeting 2 pathogenic factors in acne. • Combining a topical retinoid with an antimicrobial agent targets 3 pathogenic factors, and clinical trials have shown that comination therapy results in significantly faster and greater clearing as opposed to antimicrobial therapy alone. • Oral antibiotics should be used only in moderate-to-severe acne, should not be used as monotherapy, and should be discontinued as soon as possible (usually within 8-12 weeks). • Because of their effect on the microcomedo, topical retinoids also are recommended as an important facet of maintenance therapy.",
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Expert committee recommendations for acne management. / Zaenglein, Andrea L.; Thiboutot, Diane M.

In: Pediatrics, Vol. 118, No. 3, 01.09.2006, p. 1188-1199.

Research output: Contribution to journalReview article

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