Background: In many developed countries, immigrants live longer-that is, have lower death rates at most or all ages-than native-born residents. This article tests whether different levels of smoking-related mortality can explain part of the 'healthy immigrant effect' in the USA, as well as part of the related 'Hispanic paradox': the tendency for US Hispanics to outlive non-Hispanic Whites. Methods: With data from vital statistics and the national census, we calculate lung cancer death rates in 2000 for four US subpopulations: foreign-born, native-born, Hispanic and non-Hispanic White. We then use three different methods-the Peto-Lopez method, the Preston-Glei-Wilmoth method and a novel method developed in this article-to generate three alternative estimates of smokingrelated mortality for each of the four subpopulations, extrapolating from lung cancer death rates. We then measure the contribution of smoking-related mortality to disparities in all-cause mortality. Results: Taking estimates from any of the three methods, we find that smoking explains 450% of the difference in life expectancy at 50 years between foreign- and native-born men, and 470% of the difference between foreign- and native-born women; smoking explains475% of the difference in life expectancy at 50 years between US Hispanic and non-Hispanic White men, and close to 75% of the Hispanic advantage among women. Conclusions: Low smoking-related mortality was the main reason for immigrants' and Hispanics' longevity advantage in the USA in 2000. Published by Oxford University Press on behalf of the International Epidemiological Association.
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