Explaining patterns of infection in free-living populations using laboratory immune experiments

L. Murphy, N. Nalpas, M. Stear, I. M. Cattadori

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The host response to different helminth species can vary and have different consequences for helminth persistence. Often these differences are generated by changes in the dynamics and intensity of the immune components against parasites with distinct life history strategies. We examined the immune response of rabbits to primary infections of the gastrointestinal nematodes Trichostrongylus retortaeformis and Graphidium strigosum under controlled conditions for 120days post-challenge. Results showed that rabbits developed a robust and effective immune response against T. retortaeformis and abundance quickly decreased in the duodenum and was completely cleared in the remaining sections of the small intestine within 4months. Infected individuals exhibited an initial strong inflammatory response (IFN-γ), IL-4 expression also increased and was coupled to a rapid serum and mucus IgG and IgA and eosinophilia. Strong IL-4, serum IgA and IgG responses and eosinophilia were also observed against G. strigosum. However, parasite abundance remained consistently high throughout the infection, and this was associated with relatively low mucus antibodies. These findings suggest that immunity plays a key role in affecting the abundance of these nematodes, and different immune mechanisms are involved in regulating the dynamics of each infection and their long-term persistence in free-living host populations.

Original languageEnglish (US)
Pages (from-to)287-302
Number of pages16
JournalParasite Immunology
Volume33
Issue number5
DOIs
StatePublished - May 1 2011

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Immunology

Fingerprint Dive into the research topics of 'Explaining patterns of infection in free-living populations using laboratory immune experiments'. Together they form a unique fingerprint.

Cite this