Abstract
Pseudomonas aeruginosa and Acinetobacter baumannii are two of the main bacteria responsible for nosocomial infections; both organisms are resistant to several classes of antibiotics making their infections very difficult to treat. Moreover, they possess a remarkable ability to form biofilms, which further enhances their antimicrobial resistance. Both organisms coordinate their formation of biofilms and their expression of virulence factors through quorum sensing, a system that regulates gene expression at high cell densities and that plays a key role in the establishment of bacterial infections. Hence, interfering with these quorum-sensing systems has been proposed as an alternative to traditional antibiotics for the eradication of bacterial infections. In this review, we describe the quorum sensing systems of both organisms, the way they coordinate the formation of biofilms, the recent advances in biofilm disruption by quorum sensing interference, and the advantages and limitations of the implementation of these novel therapeutic options in the clinic.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1915-1927 |
| Number of pages | 13 |
| Journal | Current Topics in Medicinal Chemistry |
| Volume | 17 |
| Issue number | 17 |
| DOIs | |
| State | Published - Jan 1 2017 |
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All Science Journal Classification (ASJC) codes
- Drug Discovery
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Exploiting quorum sensing inhibition for the control of pseudomonas aeruginosa and acinetobacter baumannii biofilms. / Castillo-Juarez, Israel; López-Jácome, Luis Esaú; Soberón-Chávez, Gloria; Tomás, María; Lee, Jintae; Castañeda-Tamez, Paulina; Hernández-Bárragan, Iván Ángelo; Cruz-Muñiz, Martha Yumiko; Maeda, Toshinari; Wood, Thomas K.; García-Contreras, Rodolfo.
In: Current Topics in Medicinal Chemistry, Vol. 17, No. 17, 01.01.2017, p. 1915-1927.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Exploiting quorum sensing inhibition for the control of pseudomonas aeruginosa and acinetobacter baumannii biofilms
AU - Castillo-Juarez, Israel
AU - López-Jácome, Luis Esaú
AU - Soberón-Chávez, Gloria
AU - Tomás, María
AU - Lee, Jintae
AU - Castañeda-Tamez, Paulina
AU - Hernández-Bárragan, Iván Ángelo
AU - Cruz-Muñiz, Martha Yumiko
AU - Maeda, Toshinari
AU - Wood, Thomas K.
AU - García-Contreras, Rodolfo
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Pseudomonas aeruginosa and Acinetobacter baumannii are two of the main bacteria responsible for nosocomial infections; both organisms are resistant to several classes of antibiotics making their infections very difficult to treat. Moreover, they possess a remarkable ability to form biofilms, which further enhances their antimicrobial resistance. Both organisms coordinate their formation of biofilms and their expression of virulence factors through quorum sensing, a system that regulates gene expression at high cell densities and that plays a key role in the establishment of bacterial infections. Hence, interfering with these quorum-sensing systems has been proposed as an alternative to traditional antibiotics for the eradication of bacterial infections. In this review, we describe the quorum sensing systems of both organisms, the way they coordinate the formation of biofilms, the recent advances in biofilm disruption by quorum sensing interference, and the advantages and limitations of the implementation of these novel therapeutic options in the clinic.
AB - Pseudomonas aeruginosa and Acinetobacter baumannii are two of the main bacteria responsible for nosocomial infections; both organisms are resistant to several classes of antibiotics making their infections very difficult to treat. Moreover, they possess a remarkable ability to form biofilms, which further enhances their antimicrobial resistance. Both organisms coordinate their formation of biofilms and their expression of virulence factors through quorum sensing, a system that regulates gene expression at high cell densities and that plays a key role in the establishment of bacterial infections. Hence, interfering with these quorum-sensing systems has been proposed as an alternative to traditional antibiotics for the eradication of bacterial infections. In this review, we describe the quorum sensing systems of both organisms, the way they coordinate the formation of biofilms, the recent advances in biofilm disruption by quorum sensing interference, and the advantages and limitations of the implementation of these novel therapeutic options in the clinic.
UR - http://www.scopus.com/inward/record.url?scp=85021171091&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021171091&partnerID=8YFLogxK
U2 - 10.2174/1568026617666170105144104
DO - 10.2174/1568026617666170105144104
M3 - Review article
AN - SCOPUS:85021171091
VL - 17
SP - 1915
EP - 1927
JO - Current Topics in Medicinal Chemistry
JF - Current Topics in Medicinal Chemistry
SN - 1568-0266
IS - 17
ER -