TY - JOUR
T1 - Exploiting quorum sensing inhibition for the control of pseudomonas aeruginosa and acinetobacter baumannii biofilms
AU - Castillo-Juarez, Israel
AU - López-Jácome, Luis Esaú
AU - Soberón-Chávez, Gloria
AU - Tomás, María
AU - Lee, Jintae
AU - Castañeda-Tamez, Paulina
AU - Hernández-Bárragan, Iván Ángelo
AU - Cruz-Muñiz, Martha Yumiko
AU - Maeda, Toshinari
AU - Wood, Thomas K.
AU - García-Contreras, Rodolfo
N1 - Funding Information:
I C-J was supported by Fideicomiso-COLPOS 167304, C?tedras-CONACyT program and CONACYT Problemas Nacionales 2015 Program 2015-01-402, IA H-B was supported by a scholarship for undergraduate students (24008) from the SEP/CONACYT 152794 grant, M T was supported by the Miguel Servet II Programme (SERGAS and ISCIII), P C-T was supported by a scholarship for master students provided by CONACYT (430164), RG-C was supported by SEP/CONACYT 152794, UNAM-PAPIIT IA201116 and CONACYT Problemas Nacionales 2015 Program 2015-01-402. RG-C is grateful for the help of Beatriz Meraz from the Faculty of Medicine UNMA with the organization of the manuscript. T.K.W. is the Biotechnology Endowed Professor at the Pennsylvania State University.
Publisher Copyright:
© 2017 Bentham Science Publishers.
PY - 2017
Y1 - 2017
N2 - Pseudomonas aeruginosa and Acinetobacter baumannii are two of the main bacteria responsible for nosocomial infections; both organisms are resistant to several classes of antibiotics making their infections very difficult to treat. Moreover, they possess a remarkable ability to form biofilms, which further enhances their antimicrobial resistance. Both organisms coordinate their formation of biofilms and their expression of virulence factors through quorum sensing, a system that regulates gene expression at high cell densities and that plays a key role in the establishment of bacterial infections. Hence, interfering with these quorum-sensing systems has been proposed as an alternative to traditional antibiotics for the eradication of bacterial infections. In this review, we describe the quorum sensing systems of both organisms, the way they coordinate the formation of biofilms, the recent advances in biofilm disruption by quorum sensing interference, and the advantages and limitations of the implementation of these novel therapeutic options in the clinic.
AB - Pseudomonas aeruginosa and Acinetobacter baumannii are two of the main bacteria responsible for nosocomial infections; both organisms are resistant to several classes of antibiotics making their infections very difficult to treat. Moreover, they possess a remarkable ability to form biofilms, which further enhances their antimicrobial resistance. Both organisms coordinate their formation of biofilms and their expression of virulence factors through quorum sensing, a system that regulates gene expression at high cell densities and that plays a key role in the establishment of bacterial infections. Hence, interfering with these quorum-sensing systems has been proposed as an alternative to traditional antibiotics for the eradication of bacterial infections. In this review, we describe the quorum sensing systems of both organisms, the way they coordinate the formation of biofilms, the recent advances in biofilm disruption by quorum sensing interference, and the advantages and limitations of the implementation of these novel therapeutic options in the clinic.
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U2 - 10.2174/1568026617666170105144104
DO - 10.2174/1568026617666170105144104
M3 - Review article
AN - SCOPUS:85021171091
VL - 17
SP - 1915
EP - 1927
JO - Current Topics in Medicinal Chemistry
JF - Current Topics in Medicinal Chemistry
SN - 1568-0266
IS - 17
ER -