Exploiting quorum sensing inhibition for the control of pseudomonas aeruginosa and acinetobacter baumannii biofilms

Israel Castillo-Juarez, Luis Esaú López-Jácome, Gloria Soberón-Chávez, María Tomás, Jintae Lee, Paulina Castañeda-Tamez, Iván Ángelo Hernández-Bárragan, Martha Yumiko Cruz-Muñiz, Toshinari Maeda, Thomas K. Wood, Rodolfo García-Contreras

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Pseudomonas aeruginosa and Acinetobacter baumannii are two of the main bacteria responsible for nosocomial infections; both organisms are resistant to several classes of antibiotics making their infections very difficult to treat. Moreover, they possess a remarkable ability to form biofilms, which further enhances their antimicrobial resistance. Both organisms coordinate their formation of biofilms and their expression of virulence factors through quorum sensing, a system that regulates gene expression at high cell densities and that plays a key role in the establishment of bacterial infections. Hence, interfering with these quorum-sensing systems has been proposed as an alternative to traditional antibiotics for the eradication of bacterial infections. In this review, we describe the quorum sensing systems of both organisms, the way they coordinate the formation of biofilms, the recent advances in biofilm disruption by quorum sensing interference, and the advantages and limitations of the implementation of these novel therapeutic options in the clinic.

Original languageEnglish (US)
Pages (from-to)1915-1927
Number of pages13
JournalCurrent Topics in Medicinal Chemistry
Volume17
Issue number17
DOIs
StatePublished - Jan 1 2017

Fingerprint

Acinetobacter baumannii
Quorum Sensing
Biofilms
Pseudomonas aeruginosa
Bacterial Infections
Anti-Bacterial Agents
Virulence Factors
Cross Infection
Cell Count
Bacteria
Gene Expression
Infection
Therapeutics

All Science Journal Classification (ASJC) codes

  • Drug Discovery

Cite this

Castillo-Juarez, I., López-Jácome, L. E., Soberón-Chávez, G., Tomás, M., Lee, J., Castañeda-Tamez, P., ... García-Contreras, R. (2017). Exploiting quorum sensing inhibition for the control of pseudomonas aeruginosa and acinetobacter baumannii biofilms. Current Topics in Medicinal Chemistry, 17(17), 1915-1927. https://doi.org/10.2174/1568026617666170105144104
Castillo-Juarez, Israel ; López-Jácome, Luis Esaú ; Soberón-Chávez, Gloria ; Tomás, María ; Lee, Jintae ; Castañeda-Tamez, Paulina ; Hernández-Bárragan, Iván Ángelo ; Cruz-Muñiz, Martha Yumiko ; Maeda, Toshinari ; Wood, Thomas K. ; García-Contreras, Rodolfo. / Exploiting quorum sensing inhibition for the control of pseudomonas aeruginosa and acinetobacter baumannii biofilms. In: Current Topics in Medicinal Chemistry. 2017 ; Vol. 17, No. 17. pp. 1915-1927.
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abstract = "Pseudomonas aeruginosa and Acinetobacter baumannii are two of the main bacteria responsible for nosocomial infections; both organisms are resistant to several classes of antibiotics making their infections very difficult to treat. Moreover, they possess a remarkable ability to form biofilms, which further enhances their antimicrobial resistance. Both organisms coordinate their formation of biofilms and their expression of virulence factors through quorum sensing, a system that regulates gene expression at high cell densities and that plays a key role in the establishment of bacterial infections. Hence, interfering with these quorum-sensing systems has been proposed as an alternative to traditional antibiotics for the eradication of bacterial infections. In this review, we describe the quorum sensing systems of both organisms, the way they coordinate the formation of biofilms, the recent advances in biofilm disruption by quorum sensing interference, and the advantages and limitations of the implementation of these novel therapeutic options in the clinic.",
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Castillo-Juarez, I, López-Jácome, LE, Soberón-Chávez, G, Tomás, M, Lee, J, Castañeda-Tamez, P, Hernández-Bárragan, IÁ, Cruz-Muñiz, MY, Maeda, T, Wood, TK & García-Contreras, R 2017, 'Exploiting quorum sensing inhibition for the control of pseudomonas aeruginosa and acinetobacter baumannii biofilms', Current Topics in Medicinal Chemistry, vol. 17, no. 17, pp. 1915-1927. https://doi.org/10.2174/1568026617666170105144104

Exploiting quorum sensing inhibition for the control of pseudomonas aeruginosa and acinetobacter baumannii biofilms. / Castillo-Juarez, Israel; López-Jácome, Luis Esaú; Soberón-Chávez, Gloria; Tomás, María; Lee, Jintae; Castañeda-Tamez, Paulina; Hernández-Bárragan, Iván Ángelo; Cruz-Muñiz, Martha Yumiko; Maeda, Toshinari; Wood, Thomas K.; García-Contreras, Rodolfo.

In: Current Topics in Medicinal Chemistry, Vol. 17, No. 17, 01.01.2017, p. 1915-1927.

Research output: Contribution to journalReview article

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T1 - Exploiting quorum sensing inhibition for the control of pseudomonas aeruginosa and acinetobacter baumannii biofilms

AU - Castillo-Juarez, Israel

AU - López-Jácome, Luis Esaú

AU - Soberón-Chávez, Gloria

AU - Tomás, María

AU - Lee, Jintae

AU - Castañeda-Tamez, Paulina

AU - Hernández-Bárragan, Iván Ángelo

AU - Cruz-Muñiz, Martha Yumiko

AU - Maeda, Toshinari

AU - Wood, Thomas K.

AU - García-Contreras, Rodolfo

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AB - Pseudomonas aeruginosa and Acinetobacter baumannii are two of the main bacteria responsible for nosocomial infections; both organisms are resistant to several classes of antibiotics making their infections very difficult to treat. Moreover, they possess a remarkable ability to form biofilms, which further enhances their antimicrobial resistance. Both organisms coordinate their formation of biofilms and their expression of virulence factors through quorum sensing, a system that regulates gene expression at high cell densities and that plays a key role in the establishment of bacterial infections. Hence, interfering with these quorum-sensing systems has been proposed as an alternative to traditional antibiotics for the eradication of bacterial infections. In this review, we describe the quorum sensing systems of both organisms, the way they coordinate the formation of biofilms, the recent advances in biofilm disruption by quorum sensing interference, and the advantages and limitations of the implementation of these novel therapeutic options in the clinic.

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Castillo-Juarez I, López-Jácome LE, Soberón-Chávez G, Tomás M, Lee J, Castañeda-Tamez P et al. Exploiting quorum sensing inhibition for the control of pseudomonas aeruginosa and acinetobacter baumannii biofilms. Current Topics in Medicinal Chemistry. 2017 Jan 1;17(17):1915-1927. https://doi.org/10.2174/1568026617666170105144104