Exploratory studies toward a total synthesis of the marine ascidian metabolite perophoramidine

Michael A. Evans, Joshua R. Sacher, Steven M. Weinreb

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

A strategy for a total synthesis of the marine alkaloid perophoramidine has been investigated. Key steps which have been tested include a tandem intramolecular Heck/carbonylation reaction and a stereoselective allylation of a pentacyclic δ-lactam to produce the C-4/20 vicinal quaternary centers having the requisite relative configuration of the metabolite.

Original languageEnglish (US)
Pages (from-to)6712-6719
Number of pages8
JournalTetrahedron
Volume65
Issue number33
DOIs
StatePublished - Aug 15 2009

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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