Exploring functional genomics for drug target and therapeutics discovery in Plasmodia

L. Birkholtz, A. C. van Brummelen, K. Clark, J. Niemand, E. Maréchal, Manuel Llinas, A. I. Louw

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Functional genomics approaches are indispensable tools in the drug discovery arena and have recently attained increased attention in antibacterial drug discovery research. However, the application of functional genomics to post-genomics research of Plasmodia is still in comparatively early stages. Nonetheless, with this genus having the most species sequenced of any eukaryotic organism so far, the Plasmodia could provide unique opportunities for the study of intracellular eukaryotic pathogens. This review presents the status quo of functional genomics of the malaria parasite including descriptions of the transcriptome, proteome and interactome. We provide examples for the in silico mining of the X-ome data sets and illustrate how X-omic data from drug challenged parasites might be used in elucidating amongst others, the mode-of-action of inhibitory compounds, validate potential targets and discover novel targets/therapeutics.

Original languageEnglish (US)
Pages (from-to)113-123
Number of pages11
JournalActa Tropica
Volume105
Issue number2
DOIs
StatePublished - Jan 1 2008

Fingerprint

Plasmodium
Genomics
genomics
drugs
therapeutics
Drug Discovery
Pharmaceutical Preparations
Parasites
functional status
parasites
Proteome
Therapeutics
proteome
Transcriptome
Research
transcriptome
Computer Simulation
malaria
Malaria
mechanism of action

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Infectious Diseases

Cite this

Birkholtz, L., van Brummelen, A. C., Clark, K., Niemand, J., Maréchal, E., Llinas, M., & Louw, A. I. (2008). Exploring functional genomics for drug target and therapeutics discovery in Plasmodia. Acta Tropica, 105(2), 113-123. https://doi.org/10.1016/j.actatropica.2007.10.013
Birkholtz, L. ; van Brummelen, A. C. ; Clark, K. ; Niemand, J. ; Maréchal, E. ; Llinas, Manuel ; Louw, A. I. / Exploring functional genomics for drug target and therapeutics discovery in Plasmodia. In: Acta Tropica. 2008 ; Vol. 105, No. 2. pp. 113-123.
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Birkholtz, L, van Brummelen, AC, Clark, K, Niemand, J, Maréchal, E, Llinas, M & Louw, AI 2008, 'Exploring functional genomics for drug target and therapeutics discovery in Plasmodia', Acta Tropica, vol. 105, no. 2, pp. 113-123. https://doi.org/10.1016/j.actatropica.2007.10.013

Exploring functional genomics for drug target and therapeutics discovery in Plasmodia. / Birkholtz, L.; van Brummelen, A. C.; Clark, K.; Niemand, J.; Maréchal, E.; Llinas, Manuel; Louw, A. I.

In: Acta Tropica, Vol. 105, No. 2, 01.01.2008, p. 113-123.

Research output: Contribution to journalReview article

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