Abstract
Functional genomics approaches are indispensable tools in the drug discovery arena and have recently attained increased attention in antibacterial drug discovery research. However, the application of functional genomics to post-genomics research of Plasmodia is still in comparatively early stages. Nonetheless, with this genus having the most species sequenced of any eukaryotic organism so far, the Plasmodia could provide unique opportunities for the study of intracellular eukaryotic pathogens. This review presents the status quo of functional genomics of the malaria parasite including descriptions of the transcriptome, proteome and interactome. We provide examples for the in silico mining of the X-ome data sets and illustrate how X-omic data from drug challenged parasites might be used in elucidating amongst others, the mode-of-action of inhibitory compounds, validate potential targets and discover novel targets/therapeutics.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 113-123 |
| Number of pages | 11 |
| Journal | Acta Tropica |
| Volume | 105 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 2008 |
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All Science Journal Classification (ASJC) codes
- Parasitology
- Infectious Diseases
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Exploring functional genomics for drug target and therapeutics discovery in Plasmodia. / Birkholtz, L.; van Brummelen, A. C.; Clark, K.; Niemand, J.; Maréchal, E.; Llinas, Manuel; Louw, A. I.
In: Acta Tropica, Vol. 105, No. 2, 01.01.2008, p. 113-123.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Exploring functional genomics for drug target and therapeutics discovery in Plasmodia
AU - Birkholtz, L.
AU - van Brummelen, A. C.
AU - Clark, K.
AU - Niemand, J.
AU - Maréchal, E.
AU - Llinas, Manuel
AU - Louw, A. I.
PY - 2008/1/1
Y1 - 2008/1/1
N2 - Functional genomics approaches are indispensable tools in the drug discovery arena and have recently attained increased attention in antibacterial drug discovery research. However, the application of functional genomics to post-genomics research of Plasmodia is still in comparatively early stages. Nonetheless, with this genus having the most species sequenced of any eukaryotic organism so far, the Plasmodia could provide unique opportunities for the study of intracellular eukaryotic pathogens. This review presents the status quo of functional genomics of the malaria parasite including descriptions of the transcriptome, proteome and interactome. We provide examples for the in silico mining of the X-ome data sets and illustrate how X-omic data from drug challenged parasites might be used in elucidating amongst others, the mode-of-action of inhibitory compounds, validate potential targets and discover novel targets/therapeutics.
AB - Functional genomics approaches are indispensable tools in the drug discovery arena and have recently attained increased attention in antibacterial drug discovery research. However, the application of functional genomics to post-genomics research of Plasmodia is still in comparatively early stages. Nonetheless, with this genus having the most species sequenced of any eukaryotic organism so far, the Plasmodia could provide unique opportunities for the study of intracellular eukaryotic pathogens. This review presents the status quo of functional genomics of the malaria parasite including descriptions of the transcriptome, proteome and interactome. We provide examples for the in silico mining of the X-ome data sets and illustrate how X-omic data from drug challenged parasites might be used in elucidating amongst others, the mode-of-action of inhibitory compounds, validate potential targets and discover novel targets/therapeutics.
UR - http://www.scopus.com/inward/record.url?scp=38349122773&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38349122773&partnerID=8YFLogxK
U2 - 10.1016/j.actatropica.2007.10.013
DO - 10.1016/j.actatropica.2007.10.013
M3 - Review article
C2 - 18083131
AN - SCOPUS:38349122773
VL - 105
SP - 113
EP - 123
JO - Acta Tropica
JF - Acta Tropica
SN - 0001-706X
IS - 2
ER -