Exploring the lower thermal limits for development of the human malaria parasite, Plasmodium falciparum

Jessica L. Waite, Eunho Suh, Penelope A. Lynch, Matthew B. Thomas

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The rate of malaria transmission is strongly determined by parasite development time in the mosquito, known as the extrinsic incubation period (EIP), since the quicker parasites develop, the greater the chance that the vector will survive long enough for the parasite to complete development and be transmitted. EIP is known to be temperature-dependent but this relationship is surprisingly poorly characterized. There is a single degree-day model for EIP of Plasmodium falciparum that derives from a limited number of poorly controlled studies conducted almost a century ago. Here, we show that the established degree-day model greatly underestimates the rate of development of P. falciparum in both Anopheles stephensi and An. gambiae mosquitoes at temperatures in the range of 17-20°C. We also show that realistic daily temperature fluctuation further speeds parasite development. These novel results challenge one of the longest standing models in malaria biology and have potentially important implications for understanding the impacts of future climate change.

Original languageEnglish (US)
Article number20190275
JournalBiology Letters
Volume15
Issue number6
DOIs
StatePublished - Jun 1 2019

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human development
Falciparum Malaria
Plasmodium falciparum
Human Development
malaria
Parasites
Hot Temperature
heat
parasites
Culicidae
heat sums
Malaria
Temperature
Anopheles stephensi
temperature
Anopheles
Climate Change
climate change
Biological Sciences

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences (miscellaneous)
  • Agricultural and Biological Sciences(all)

Cite this

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abstract = "The rate of malaria transmission is strongly determined by parasite development time in the mosquito, known as the extrinsic incubation period (EIP), since the quicker parasites develop, the greater the chance that the vector will survive long enough for the parasite to complete development and be transmitted. EIP is known to be temperature-dependent but this relationship is surprisingly poorly characterized. There is a single degree-day model for EIP of Plasmodium falciparum that derives from a limited number of poorly controlled studies conducted almost a century ago. Here, we show that the established degree-day model greatly underestimates the rate of development of P. falciparum in both Anopheles stephensi and An. gambiae mosquitoes at temperatures in the range of 17-20°C. We also show that realistic daily temperature fluctuation further speeds parasite development. These novel results challenge one of the longest standing models in malaria biology and have potentially important implications for understanding the impacts of future climate change.",
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Exploring the lower thermal limits for development of the human malaria parasite, Plasmodium falciparum. / Waite, Jessica L.; Suh, Eunho; Lynch, Penelope A.; Thomas, Matthew B.

In: Biology Letters, Vol. 15, No. 6, 20190275, 01.06.2019.

Research output: Contribution to journalArticle

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