Exposure assessment

Serum levels of TCDD in Seveso, Italy

L. L. Needham, P. M. Gerthoux, Donald George Jr Patterson, P. Brambilla, S. J. Smith, E. J. Sampson, P. Mocarelli

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Accurate exposure assessment is an important step in both risk assessment and epidemiologic studies involving potential human exposure to environmental toxicants. Various methods have been used to assess human exposure. These methods include models based on one's temporal and spatial nearness to the source, environmental levels of toxicant, and biological measures. We believe that the latter measure is the 'gold standard.' In this article we present the serum 2,3,7,8-tetrachlorodibenzo-p-dioxin levels in residents of the contaminated zones in Seveso, Italy, in 1976, and delineate these data by age and gender. Some of these serum levels are among the highest ever reported and thus this population serves as a benchmark for comparison of human exposure and potential adverse health effects. One such potential population is that population consuming potentially contaminated fish.

Original languageEnglish (US)
JournalEnvironmental Research
Volume80
Issue number2 II
DOIs
StatePublished - Jan 1 1999

Fingerprint

TCDD
Risk assessment
Fish
Italy
serum
Health
Serum
Population
Benchmarking
Environmental Exposure
Epidemiologic Studies
Fishes
dioxin
gender
risk assessment
gold
Polychlorinated Dibenzodioxins
exposure
1,4-dioxin
fish

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Environmental Science(all)

Cite this

Needham, L. L., Gerthoux, P. M., Patterson, D. G. J., Brambilla, P., Smith, S. J., Sampson, E. J., & Mocarelli, P. (1999). Exposure assessment: Serum levels of TCDD in Seveso, Italy. Environmental Research, 80(2 II). https://doi.org/10.1006/enrs.1998.3928
Needham, L. L. ; Gerthoux, P. M. ; Patterson, Donald George Jr ; Brambilla, P. ; Smith, S. J. ; Sampson, E. J. ; Mocarelli, P. / Exposure assessment : Serum levels of TCDD in Seveso, Italy. In: Environmental Research. 1999 ; Vol. 80, No. 2 II.
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Needham, LL, Gerthoux, PM, Patterson, DGJ, Brambilla, P, Smith, SJ, Sampson, EJ & Mocarelli, P 1999, 'Exposure assessment: Serum levels of TCDD in Seveso, Italy', Environmental Research, vol. 80, no. 2 II. https://doi.org/10.1006/enrs.1998.3928

Exposure assessment : Serum levels of TCDD in Seveso, Italy. / Needham, L. L.; Gerthoux, P. M.; Patterson, Donald George Jr; Brambilla, P.; Smith, S. J.; Sampson, E. J.; Mocarelli, P.

In: Environmental Research, Vol. 80, No. 2 II, 01.01.1999.

Research output: Contribution to journalArticle

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Needham LL, Gerthoux PM, Patterson DGJ, Brambilla P, Smith SJ, Sampson EJ et al. Exposure assessment: Serum levels of TCDD in Seveso, Italy. Environmental Research. 1999 Jan 1;80(2 II). https://doi.org/10.1006/enrs.1998.3928