Expression and function of tetraspanins and their interacting partners in B cells

Fagui Zou, Xu Wang, Xinxin Han, Gerson Rothschild, Song Guo Zheng, Uttiya Basu, Jianbo Sun

Research output: Contribution to journalReview article

Abstract

Tetraspanins are transmembrane proteins that modulate multiple diverse biological processes, including signal transduction, cell-cell communication, immunoregulation, tumorigenesis, cell adhesion, migration, and growth and differentiation. Here, we provide a systematic review of the involvement of tetraspanins and their partners in the regulation and function of B cells, including mechanisms associated with antigen presentation, antibody production, cytokine secretion, co-stimulator expression, and immunosuppression. Finally, we direct our focus to the signaling mechanisms, evolutionary conservation aspects, expression, and potential therapeutic strategies that could be based on tetraspanins and their interacting partners.

LanguageEnglish (US)
Article number1606
JournalFrontiers in Immunology
Volume9
Issue numberJUL
DOIs
StatePublished - Jul 18 2018

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Tetraspanins
B-Lymphocytes
Biological Phenomena
Antigen Presentation
Cell Adhesion
Cell Communication
Immunosuppression
Antibody Formation
Cell Movement
Signal Transduction
Carcinogenesis
Cytokines
Growth
Proteins
Therapeutics

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Zou, F., Wang, X., Han, X., Rothschild, G., Zheng, S. G., Basu, U., & Sun, J. (2018). Expression and function of tetraspanins and their interacting partners in B cells. Frontiers in Immunology, 9(JUL), [1606]. DOI: 10.3389/fimmu.2018.01606
Zou, Fagui ; Wang, Xu ; Han, Xinxin ; Rothschild, Gerson ; Zheng, Song Guo ; Basu, Uttiya ; Sun, Jianbo. / Expression and function of tetraspanins and their interacting partners in B cells. In: Frontiers in Immunology. 2018 ; Vol. 9, No. JUL.
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Zou, F, Wang, X, Han, X, Rothschild, G, Zheng, SG, Basu, U & Sun, J 2018, 'Expression and function of tetraspanins and their interacting partners in B cells' Frontiers in Immunology, vol. 9, no. JUL, 1606. DOI: 10.3389/fimmu.2018.01606

Expression and function of tetraspanins and their interacting partners in B cells. / Zou, Fagui; Wang, Xu; Han, Xinxin; Rothschild, Gerson; Zheng, Song Guo; Basu, Uttiya; Sun, Jianbo.

In: Frontiers in Immunology, Vol. 9, No. JUL, 1606, 18.07.2018.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Expression and function of tetraspanins and their interacting partners in B cells

AU - Zou,Fagui

AU - Wang,Xu

AU - Han,Xinxin

AU - Rothschild,Gerson

AU - Zheng,Song Guo

AU - Basu,Uttiya

AU - Sun,Jianbo

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AB - Tetraspanins are transmembrane proteins that modulate multiple diverse biological processes, including signal transduction, cell-cell communication, immunoregulation, tumorigenesis, cell adhesion, migration, and growth and differentiation. Here, we provide a systematic review of the involvement of tetraspanins and their partners in the regulation and function of B cells, including mechanisms associated with antigen presentation, antibody production, cytokine secretion, co-stimulator expression, and immunosuppression. Finally, we direct our focus to the signaling mechanisms, evolutionary conservation aspects, expression, and potential therapeutic strategies that could be based on tetraspanins and their interacting partners.

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Zou F, Wang X, Han X, Rothschild G, Zheng SG, Basu U et al. Expression and function of tetraspanins and their interacting partners in B cells. Frontiers in Immunology. 2018 Jul 18;9(JUL). 1606. Available from, DOI: 10.3389/fimmu.2018.01606