Expression and function of trk-C in favourable human neuroblastomas

D. J. Yamashiro, X. G. Liu, C. P. Lee, A. Nakagawara, N. Ikegaki, L. M. McGregor, S. B. Baylin, G. M. Brodeur

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43 Scopus citations

Abstract

Human neuroblastomas express the neurotrophin receptors trk-A and trk- B. Favourable outcome is associated with expression of trk-A, while unfavourable, MYCN amplified tumours express trk-B. In this study we examined the expression of trk-C in primary neuroblastoma tumour-derived cell lines. We found by Northern blot analysis that trk-C mRNA is expressed in 14 of 55 (25%) primary tumours. Trk-C was expressed in significantly more lower stage tumours (stage 1, 2, 4S) than higher stage tumours (stage 3, 4, P < 0.04). The expression of trk-C was correlated positively with survival and negatively correlated with MYCN amplification. We also studied the function of trk-C in transfected cell lines and found that NT-3 promotes both cell survival and differentiation. Our results suggest that trk-C is involved in the biology of favourable neuroblastomas.

Original languageEnglish (US)
Pages (from-to)2054-2057
Number of pages4
JournalEuropean Journal of Cancer
Volume33
Issue number12
DOIs
StatePublished - Oct 1 1997

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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