Objective To investigate the expression of nm23-H1 in epithelial ovarian cancer. Methods A total of 55 specimens from patients with epithelial ovarian cancers, 15 patients with serous cancers, 7 with mucinous cancers, 17 with endometriord cancers and 16 with adenocarcinomas, were examined for the expression of nm23-H1 by means of the immunohistochemical technique. Results The total positive rate was 23.64% (13/55). The tissular nm23-H1 immunostaimng had significantly higher expression in mucinous cancer (57.14%) than in other histologic types of epithelial ovarian cancer (P<0.05). Compared to that in the primary tumor, nm23-H1 expression in the omental metastatic tumor in the same patient was reduced. Conclusions The expression rate of nm23-H1 is higher in the primary tumors than in the metastatic tumors and is different in various histologic subtypes of epithelial ovarian cancer. The expression of nm23-H1 may participate in the inhibitory process of tumor invasion.
|Original language||English (US)|
|Number of pages||3|
|Journal||Chinese Medical Journal|
|State||Published - 1997|
All Science Journal Classification (ASJC) codes