Expression of antimetastatic gene nm23-H1 in epithelial ovarian cancer

Ming Qian, Youji Feng, Liangzhong Xu, Songguo Zheng, Xianrong Zhou

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5 Scopus citations

Abstract

Objective To investigate the expression of nm23-H1 in epithelial ovarian cancer. Methods A total of 55 specimens from patients with epithelial ovarian cancers, 15 patients with serous cancers, 7 with mucinous cancers, 17 with endometriord cancers and 16 with adenocarcinomas, were examined for the expression of nm23-H1 by means of the immunohistochemical technique. Results The total positive rate was 23.64% (13/55). The tissular nm23-H1 immunostaimng had significantly higher expression in mucinous cancer (57.14%) than in other histologic types of epithelial ovarian cancer (P<0.05). Compared to that in the primary tumor, nm23-H1 expression in the omental metastatic tumor in the same patient was reduced. Conclusions The expression rate of nm23-H1 is higher in the primary tumors than in the metastatic tumors and is different in various histologic subtypes of epithelial ovarian cancer. The expression of nm23-H1 may participate in the inhibitory process of tumor invasion.

Original languageEnglish (US)
Pages (from-to)142-144
Number of pages3
JournalChinese Medical Journal
Volume110
Issue number2
StatePublished - 1997

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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