Expression of CK7, Cam 5.2 and Ber-Ep4 in cutaneous squamous cell carcinoma

Loren E. Clarke; Andrea B. Conway; Nicole M. Warner; Patricia N. Barnwell; Jennifer Sceppa; Klaus Helm

doi:10.1111/cup.12135

Expression of CK7, Cam 5.2 and Ber-Ep4 in cutaneous squamous cell carcinoma

Loren E. Clarke, Andrea B. Conway, Nicole M. Warner, Patricia N. Barnwell, Jennifer Sceppa, Klaus Helm

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Background Cytokeratin 7 (CK7) and Cam 5.2 are often used to differentiate extramammary Paget's disease (EPD) from squamous cell carcinoma (SCC) in situ because they are generally considered to be expressed in the former but not in the latter. However, we have encountered CK7+ and Cam 5.2+ SCCs. Methods We evaluated CK7, Cam 5.2 and Ber-Ep4 expression in SCC and EPD. Results We found significant CK7 and Cam 5.2 positivity in SCCs, particularly in those with a pagetoid pattern. Only one case expressed Ber-Ep4. Conclusions We conclude that CK7 and Cam 5.2 expression may occur in SCC. A panel including Ber-Ep4 is advisable for immunohistochemical differentiation of EPD from SCC.

Original language	English (US)
Pages (from-to)	646-650
Number of pages	5
Journal	Journal of Cutaneous Pathology
Volume	40
Issue number	7
DOIs	https://doi.org/10.1111/cup.12135
State	Published - Jul 2013

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Histology
Dermatology

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10.1111/cup.12135

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title = "Expression of CK7, Cam 5.2 and Ber-Ep4 in cutaneous squamous cell carcinoma",

abstract = "Background Cytokeratin 7 (CK7) and Cam 5.2 are often used to differentiate extramammary Paget's disease (EPD) from squamous cell carcinoma (SCC) in situ because they are generally considered to be expressed in the former but not in the latter. However, we have encountered CK7+ and Cam 5.2+ SCCs. Methods We evaluated CK7, Cam 5.2 and Ber-Ep4 expression in SCC and EPD. Results We found significant CK7 and Cam 5.2 positivity in SCCs, particularly in those with a pagetoid pattern. Only one case expressed Ber-Ep4. Conclusions We conclude that CK7 and Cam 5.2 expression may occur in SCC. A panel including Ber-Ep4 is advisable for immunohistochemical differentiation of EPD from SCC.",

author = "Clarke, {Loren E.} and Conway, {Andrea B.} and Warner, {Nicole M.} and Barnwell, {Patricia N.} and Jennifer Sceppa and Klaus Helm",

year = "2013",

month = jul,

doi = "10.1111/cup.12135",

language = "English (US)",

volume = "40",

pages = "646--650",

journal = "Journal of Cutaneous Pathology",

issn = "0303-6987",

publisher = "Wiley-Blackwell",

number = "7",

}

TY - JOUR

T1 - Expression of CK7, Cam 5.2 and Ber-Ep4 in cutaneous squamous cell carcinoma

AU - Clarke, Loren E.

AU - Conway, Andrea B.

AU - Warner, Nicole M.

AU - Barnwell, Patricia N.

AU - Sceppa, Jennifer

AU - Helm, Klaus

PY - 2013/7

Y1 - 2013/7

N2 - Background Cytokeratin 7 (CK7) and Cam 5.2 are often used to differentiate extramammary Paget's disease (EPD) from squamous cell carcinoma (SCC) in situ because they are generally considered to be expressed in the former but not in the latter. However, we have encountered CK7+ and Cam 5.2+ SCCs. Methods We evaluated CK7, Cam 5.2 and Ber-Ep4 expression in SCC and EPD. Results We found significant CK7 and Cam 5.2 positivity in SCCs, particularly in those with a pagetoid pattern. Only one case expressed Ber-Ep4. Conclusions We conclude that CK7 and Cam 5.2 expression may occur in SCC. A panel including Ber-Ep4 is advisable for immunohistochemical differentiation of EPD from SCC.

AB - Background Cytokeratin 7 (CK7) and Cam 5.2 are often used to differentiate extramammary Paget's disease (EPD) from squamous cell carcinoma (SCC) in situ because they are generally considered to be expressed in the former but not in the latter. However, we have encountered CK7+ and Cam 5.2+ SCCs. Methods We evaluated CK7, Cam 5.2 and Ber-Ep4 expression in SCC and EPD. Results We found significant CK7 and Cam 5.2 positivity in SCCs, particularly in those with a pagetoid pattern. Only one case expressed Ber-Ep4. Conclusions We conclude that CK7 and Cam 5.2 expression may occur in SCC. A panel including Ber-Ep4 is advisable for immunohistochemical differentiation of EPD from SCC.

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Expression of CK7, Cam 5.2 and Ber-Ep4 in cutaneous squamous cell carcinoma

Abstract

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