Expression of HLA system antigens on placenta

P. N. Goodfellow, Colin Barnstable, W. F. Bodmer, D. Snary, M. J. Crumpton

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

The levels of HLA-A and -B antigens expressed by placenta have been assessed relative to parental and other A and B antigen types that were not shared by the foetus. A purified preparation of placenta plasma membrane was used to estimate the antigen activities. The results indicate that maternally and paternally inherited A and B antigen activities and ß2-microglobulin are expressed to similar extents but at much lower levels than in spleen lymphocytes (less than 5%). The possibility that the amounts detected were caused by contamination with blood or maternal tissue was ruled out. The low levels of A and B antigens may account for the lack of a cellular immune response to the other polymorphic cell surface antigens of the trophoblast. No evidence was obtained for the expression of a significant level of Ia antigens.

Original languageEnglish (US)
Pages (from-to)595-603
Number of pages9
JournalTransplantation
Volume22
Issue number6
DOIs
StatePublished - Jan 1 1976

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HLA Antigens
Placenta
Antigens
HLA-A Antigens
HLA-B Antigens
Histocompatibility Antigens Class II
Trophoblasts
Surface Antigens
Cellular Immunity
Fetus
Spleen
Mothers
Cell Membrane
Lymphocytes

All Science Journal Classification (ASJC) codes

  • Transplantation

Cite this

Goodfellow, P. N., Barnstable, C., Bodmer, W. F., Snary, D., & Crumpton, M. J. (1976). Expression of HLA system antigens on placenta. Transplantation, 22(6), 595-603. https://doi.org/10.1097/00007890-197612000-00009
Goodfellow, P. N. ; Barnstable, Colin ; Bodmer, W. F. ; Snary, D. ; Crumpton, M. J. / Expression of HLA system antigens on placenta. In: Transplantation. 1976 ; Vol. 22, No. 6. pp. 595-603.
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Goodfellow, PN, Barnstable, C, Bodmer, WF, Snary, D & Crumpton, MJ 1976, 'Expression of HLA system antigens on placenta', Transplantation, vol. 22, no. 6, pp. 595-603. https://doi.org/10.1097/00007890-197612000-00009

Expression of HLA system antigens on placenta. / Goodfellow, P. N.; Barnstable, Colin; Bodmer, W. F.; Snary, D.; Crumpton, M. J.

In: Transplantation, Vol. 22, No. 6, 01.01.1976, p. 595-603.

Research output: Contribution to journalArticle

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