Expression of messenger rna for insulin-like growth factors and insulin-like growth factor binding proteins by experimental breast cancer and normal breast tissue in vivo

Andrea Manni, L. Wei, B. Badger, Andrea Zaenglein, J. Leighton, S. Shimasaki, N. Ling

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

We report the expression of insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) by breast cancer cells and normal breast tissue in vivo. N-nitrosomethyl-urea (NMU)-induced rat mammary tumors synthesize mRNAs for IGF-II and IGFBP-2, -3, and -4. In contrast, normal lactating breast contains only IGFBP-2 and IGF-I! messages; IGFBP-3 and -4 mRNAs are absent !n this tissue, IGF-I and IGFBP-1 mRNAs are not expressed in either NMU tumors or in normal breast. This is the first report of in vivo expression of IGFBPs and IGF-II messages in breast tumors.

Original languageEnglish (US)
Pages (from-to)1744-1746
Number of pages3
JournalEndocrinology
Volume130
Issue number3
DOIs
StatePublished - Mar 1992

All Science Journal Classification (ASJC) codes

  • Endocrinology

Fingerprint Dive into the research topics of 'Expression of messenger rna for insulin-like growth factors and insulin-like growth factor binding proteins by experimental breast cancer and normal breast tissue in vivo'. Together they form a unique fingerprint.

  • Cite this