Expression of Transferrin mRNA in the CNS of Normal and Jimpy Mice

William P. Bartlett, Xiao‐Su ‐S Li, James R. Connor

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

Abstract: Both the iron mobilization protein transferrin and iron itself are found predominantly in oligodendrocytes in the brain and consequently have been hypothesized to have a role in myelination. This study is designed to begin to understand the mechanism(s) that control the expression of transferrin at the gene level in the nervous system using a hypomyelinating murine mutant (jimpy mouse). With this animal model it is possible to determine if transferrin gene expression in the nervous system is dependent on the presence of a mature oligodendrocytic population. The results demonstrate that normally expression of the transferrin gene increases from postnatal day 5 to 22–25 and then levels off in the adult. In the jimpy mouse, the relative amount of transferrin gene expression is less than that of littermate controls at 5 days of age. Furthermore, transferrin gene expression does not increase with age beyond the level observed at postnatal day 5 in the jimpy mouse. It is concluded from this study that the majority of the transferrin mRNA in the mouse brain is expressed by and/or requires the presence of a mature oligodendrocytic population.

Original languageEnglish (US)
Pages (from-to)318-322
Number of pages5
JournalJournal of neurochemistry
Volume57
Issue number1
DOIs
StatePublished - Jul 1991

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

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