Expression of viral T-antigen in pathological tissues from transgenic mice carrying JC-SV40 chimeric DNAs

Holly G. Ressetar, Om Prakash, Richard J. Frisque, Henry deF. Webster, Richard N. Re, Gerald L. Stoner

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Immunostaining methods were used to detect viral T-antigen and the cellular protein p53 in pathological tissues obtained from transgenic mice carrying JC-SV40 hybrid viral DNAs. A transgenic mouse carrying the SV40 regulatory region and JC virus (JCV) T-antigen-coding sequences exhibited an SV40-characteristic choroid plexus papilloma that expressed JCV T-antigen and p53. JCV-associated pathology was observed in two other mice in which the JCV regulatory signals directed SV40 T-antigen-induced adrenal neuroblastomas and brain neoplastic cells. However, these mice also exhibited an SV40-characteristic osteosarcoma and abdominal lymphoma that contained SV40 T-antigen and p53-positive cells. Contrasting thymic pathology was observed in the two types of mice where the SV40 regulatory region directed a JCV T-antigen-induced thymoma in one mouse, and the JCV regulatory region directed SV40 T-antigen-induced thymic hypoplasia in two other mice.

Original languageEnglish (US)
Pages (from-to)59-79
Number of pages21
JournalMolecular and Chemical Neuropathology
Volume20
Issue number1
DOIs
StatePublished - Sep 1993

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology

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