Extended Mycophenolate Mofetil Administration Beyond Day 30 in Allogeneic Hematopoietic Stem Cell Transplantation as Preemptive Therapy for Severe Graft-Versus-Host Disease

S. Nishikawa, A. Okamura, M. Yamamori, K. Minagawa, Y. Kawamori, Y. Kawano, H. Kawano, K. Ono, Y. Katayama, M. Shimoyama, T. Matsui

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

To prevent acute graft-versus-host disease (GVHD), mycophenolate mofetil (MMF) combined with calcineurin inhibitors have been used in allogeneic hematopoietic stem cell transplantation (allo-SCT). Previous studies commonly utilize MMF treatment until day 30 after allo-SCT. However, the feasibility of continuous administration after day 30 has not been well evaluated. We retrospectively assessed the safety and efficacy of extended drug administration. Twenty-five patients ceased MMF at day 30 (group A); whereas, 16 patients (group B) received extended regimens depending on individual risk factors for GVHD. No severe adverse events were observed in either group. Although the cumulative incidence (CI) of grade I to IV GVHD at day 100 was comparable between the 2 groups, the CI of grade II to IV GVHD was less among group B (12.5%) compared with group A (42.3%). Extended MMF administration may be safe and beneficial as preemptive therapy to reduce the development of moderate-to-severe acute GVHD.

Original languageEnglish (US)
Pages (from-to)3873-3876
Number of pages4
JournalTransplantation proceedings
Volume41
Issue number9
DOIs
StatePublished - Nov 2009

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

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