Pummerer chemistry applied to 2-sulfinyl indoles promotes oxidative cyclization of pendant nucleophiles to furnish C(3) spirocyclic indolenine products. Use of tetrasubstituted silyl enol ether nucleophiles in this transform yields spirocycles featuring vicinal all-carbon quaternary centers in two cases, but fails when a nearby amine can intervene.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Apr 29 2009|
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry