Extension of Corpus Luteum Lifespan and Reduction of Uterine Secretion of Prostaglandin F of Cows in Response to Recombinant Interferon-τ

M. D. Meyer, P. J. Hansen, W. W. Thatcher, M. Drost, L. Badinga, R. M. Roberts, J. Li, T. L. Ott, F. W. Bazer

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Abstract

Two experiments tested the effect of recombinant ovine and bovine interferon-τ on corpus luteum lifespan, interestrous interval, and oxytocin-induced uterine secretion of prostaglandin F. Cows received intrauterine injections of 100 μg of recombinant ovine interferon-τ plus 1.4 mg of BSA or of 1.5 mg of BSA alone in Experiment 1 and 200 μg of recombinant bovine interferon-τ plus 1.3 mg of BSA or 1.5 mg of BSA alone in Experiment 2. Twice daily injections (0700 and 1900 h) were split evenly between the uterine horns from d 14 to 24 of the experimental estrous cycle via an AI pipette in Experiment 1 and via intrauterine catheters in Experiment 2. On d 17, cows were injected with 100 IU of oxytocin, and plasma was collected for analysis of 13,14-dihydro-15-keto-prostaglandinF. Recombinant ovine interferon-τ extended the lifespan of the corpus luteum (27.5 vs. 19.2 d) and interestrous interval (30.5 vs. 20.6 d) and abolished the oxytocin-induced increase in 13,14-dihydro-15-keto-prostaglandinF, which peaked at 30 min for the BSA control group (210.8 pg/ml). Recombinant bovine interferon-τ also extended the lifespan of the corpus luteum (29.0 vs. 21.4 d) and interestrous interval (31.5 vs. 22.6 d) and abolished the oxytocin-induced increase in 13,14-dihydro-15-keto-prostaglandin F, which peaked at 30 min for the BSA control group (205.6 pg/ml). In conclusion, recombinant ovine interferon-τ and recombinant bovine interferon-τ were effective antiluteolytic agents in cattle.

Original languageEnglish (US)
Pages (from-to)1921-1931
Number of pages11
JournalJournal of dairy science
Volume78
Issue number9
DOIs
StatePublished - 1995

All Science Journal Classification (ASJC) codes

  • Food Science
  • Animal Science and Zoology
  • Genetics

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