Extensive MHC variability in cichlid fishes of Lake Malawi

Dagmar Klein, Hideki Ono, Colm O'Huigin, Vladimir Vincek, Tijs Goldschmidt, Jan Klein

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

LAKE Malawi in East Africa harbours 500-1,000 endemic species of cichlid fishes, all presumably derived by adaptive radiation from a single founding population within the past two million years1-3. The species of this 'flock' differ strikingly in their ecology and behaviour4, moderately in their external morphology1 and very little in their molecular characteristics5,6. Here we describe high sequence variability of class II major histocompatibility complex genes in a sample of species from Lake Malawi. The variability provides a set of molecular markers for studying adaptive radiation and should be useful for estimating the size of the population that founded the species flock.

Original languageEnglish (US)
Pages (from-to)330-334
Number of pages5
JournalNature
Volume364
Issue number6435
DOIs
StatePublished - Jan 1 1993

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Cichlids
Malawi
Lakes
Radiation
Eastern Africa
Population Density
Ecology
Major Histocompatibility Complex
Population
Genes

All Science Journal Classification (ASJC) codes

  • General

Cite this

Klein, D., Ono, H., O'Huigin, C., Vincek, V., Goldschmidt, T., & Klein, J. (1993). Extensive MHC variability in cichlid fishes of Lake Malawi. Nature, 364(6435), 330-334. https://doi.org/10.1038/364330a0
Klein, Dagmar ; Ono, Hideki ; O'Huigin, Colm ; Vincek, Vladimir ; Goldschmidt, Tijs ; Klein, Jan. / Extensive MHC variability in cichlid fishes of Lake Malawi. In: Nature. 1993 ; Vol. 364, No. 6435. pp. 330-334.
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Klein, D, Ono, H, O'Huigin, C, Vincek, V, Goldschmidt, T & Klein, J 1993, 'Extensive MHC variability in cichlid fishes of Lake Malawi', Nature, vol. 364, no. 6435, pp. 330-334. https://doi.org/10.1038/364330a0

Extensive MHC variability in cichlid fishes of Lake Malawi. / Klein, Dagmar; Ono, Hideki; O'Huigin, Colm; Vincek, Vladimir; Goldschmidt, Tijs; Klein, Jan.

In: Nature, Vol. 364, No. 6435, 01.01.1993, p. 330-334.

Research output: Contribution to journalArticle

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Klein D, Ono H, O'Huigin C, Vincek V, Goldschmidt T, Klein J. Extensive MHC variability in cichlid fishes of Lake Malawi. Nature. 1993 Jan 1;364(6435):330-334. https://doi.org/10.1038/364330a0