External electric field effect on the PR neuronal firing under the ephaptic transmission

Xile Wei, Yinhong Chen, Jiang Wang, Bin Deng, Meili Lu, Yanqiu Che

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The external electric field (EF) has shown to have great influence on neurons. On account of the effects of applied fields on neural activity through the induced EF in the extracellular medium, the electrical characteristics of the extracellular medium should not be ignored for accurately reflecting the biological field effect. Here considering the electrical characteristic of extracellular medium i.e. ephaptic transmission, neuronal firing is studied based on a PR neuron model in the presence of the external (EF), including direct current (DC) and alternating current (AC) EF. Moreover, three key parameters (the inner conductance g c, the inverted potential of potassium ion V K and the extracellular resistance between dendrite and soma R out DS), which are crucial for the dynamics of neurons, are introduced to develop the neuronal firing. Different firing rhythms of neuron imply different stimulus information, and in some particular stimulus frequency the synchronization between the firing rhythm and EF signal is observed.

Original languageEnglish (US)
Title of host publicationProceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011
Pages1839-1843
Number of pages5
DOIs
StatePublished - 2011
Event2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011 - Shanghai, China
Duration: Oct 15 2011Oct 17 2011

Publication series

NameProceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011
Volume4

Other

Other2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011
CountryChina
CityShanghai
Period10/15/1110/17/11

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management

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  • Cite this

    Wei, X., Chen, Y., Wang, J., Deng, B., Lu, M., & Che, Y. (2011). External electric field effect on the PR neuronal firing under the ephaptic transmission. In Proceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011 (pp. 1839-1843). [6098722] (Proceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 2011; Vol. 4). https://doi.org/10.1109/BMEI.2011.6098722