Extraesophageal reflux in children

Linda Brodsky, Michele M. Carr

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: To summarize and contextualize current concepts in the incidence, diagnosis, management and long-term sequelae of extraesophageal reflux disease in children. RECENT FINDINGS: Extraesophageal reflux disease is a different disease entity from gastroesophageal reflux disease. The two diseases have a common etiology, refluxate causing mucosal damage, but the extent and location of the damage varies considerably depending on the underlying mucosal characteristics. Extraesophageal reflux disease in children is characterized by a broad set of symptoms and signs that vary according to age at presentation and severity of disease. Serious long-term effects begin in childhood. The role of pepsin, bile acids, pancreatic enzymes, motility disorders, and food allergies have only recently been recognized. Newer diagnostic modalities include multichannel intraluminal pH/impedance, the 48 h Bravo implantable probe, and hypopharyngeal pH monitoring. While proton pump inhibitors provide superior acid suppression compared with histamine-2 blockers, variability in response and lack of efficacy for alkaline refluxate often require other therapeutic interventions. SUMMARY: Pediatric extraesophageal reflux disease has variable presentation and a gold standard test is still lacking. Primary treatment includes lifestyle and feeding changes and medical therapy. Ongoing monitoring for recurrence and agreement as to duration of therapy present significant challenges not yet standardized amongst practitioners.

Original languageEnglish (US)
Pages (from-to)387-392
Number of pages6
JournalCurrent Opinion in Otolaryngology and Head and Neck Surgery
Volume14
Issue number6
DOIs
StatePublished - Dec 1 2006

Fingerprint

tetrachloroisophthalonitrile
Food Hypersensitivity
Proton Pump Inhibitors
Pepsin A
Therapeutics
Gastroesophageal Reflux
Bile Acids and Salts
Electric Impedance
Histamine
Signs and Symptoms
Life Style
Pediatrics
Recurrence
Acids
Incidence
Enzymes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Otorhinolaryngology

Cite this

Brodsky, Linda ; Carr, Michele M. / Extraesophageal reflux in children. In: Current Opinion in Otolaryngology and Head and Neck Surgery. 2006 ; Vol. 14, No. 6. pp. 387-392.
@article{f9a232b77aa6453c955f7037b106e075,
title = "Extraesophageal reflux in children",
abstract = "PURPOSE OF REVIEW: To summarize and contextualize current concepts in the incidence, diagnosis, management and long-term sequelae of extraesophageal reflux disease in children. RECENT FINDINGS: Extraesophageal reflux disease is a different disease entity from gastroesophageal reflux disease. The two diseases have a common etiology, refluxate causing mucosal damage, but the extent and location of the damage varies considerably depending on the underlying mucosal characteristics. Extraesophageal reflux disease in children is characterized by a broad set of symptoms and signs that vary according to age at presentation and severity of disease. Serious long-term effects begin in childhood. The role of pepsin, bile acids, pancreatic enzymes, motility disorders, and food allergies have only recently been recognized. Newer diagnostic modalities include multichannel intraluminal pH/impedance, the 48 h Bravo implantable probe, and hypopharyngeal pH monitoring. While proton pump inhibitors provide superior acid suppression compared with histamine-2 blockers, variability in response and lack of efficacy for alkaline refluxate often require other therapeutic interventions. SUMMARY: Pediatric extraesophageal reflux disease has variable presentation and a gold standard test is still lacking. Primary treatment includes lifestyle and feeding changes and medical therapy. Ongoing monitoring for recurrence and agreement as to duration of therapy present significant challenges not yet standardized amongst practitioners.",
author = "Linda Brodsky and Carr, {Michele M.}",
year = "2006",
month = "12",
day = "1",
doi = "10.1097/MOO.0b013e3280106326",
language = "English (US)",
volume = "14",
pages = "387--392",
journal = "Current Opinion in Otolaryngology and Head and Neck Surgery",
issn = "1068-9508",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

Extraesophageal reflux in children. / Brodsky, Linda; Carr, Michele M.

In: Current Opinion in Otolaryngology and Head and Neck Surgery, Vol. 14, No. 6, 01.12.2006, p. 387-392.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Extraesophageal reflux in children

AU - Brodsky, Linda

AU - Carr, Michele M.

PY - 2006/12/1

Y1 - 2006/12/1

N2 - PURPOSE OF REVIEW: To summarize and contextualize current concepts in the incidence, diagnosis, management and long-term sequelae of extraesophageal reflux disease in children. RECENT FINDINGS: Extraesophageal reflux disease is a different disease entity from gastroesophageal reflux disease. The two diseases have a common etiology, refluxate causing mucosal damage, but the extent and location of the damage varies considerably depending on the underlying mucosal characteristics. Extraesophageal reflux disease in children is characterized by a broad set of symptoms and signs that vary according to age at presentation and severity of disease. Serious long-term effects begin in childhood. The role of pepsin, bile acids, pancreatic enzymes, motility disorders, and food allergies have only recently been recognized. Newer diagnostic modalities include multichannel intraluminal pH/impedance, the 48 h Bravo implantable probe, and hypopharyngeal pH monitoring. While proton pump inhibitors provide superior acid suppression compared with histamine-2 blockers, variability in response and lack of efficacy for alkaline refluxate often require other therapeutic interventions. SUMMARY: Pediatric extraesophageal reflux disease has variable presentation and a gold standard test is still lacking. Primary treatment includes lifestyle and feeding changes and medical therapy. Ongoing monitoring for recurrence and agreement as to duration of therapy present significant challenges not yet standardized amongst practitioners.

AB - PURPOSE OF REVIEW: To summarize and contextualize current concepts in the incidence, diagnosis, management and long-term sequelae of extraesophageal reflux disease in children. RECENT FINDINGS: Extraesophageal reflux disease is a different disease entity from gastroesophageal reflux disease. The two diseases have a common etiology, refluxate causing mucosal damage, but the extent and location of the damage varies considerably depending on the underlying mucosal characteristics. Extraesophageal reflux disease in children is characterized by a broad set of symptoms and signs that vary according to age at presentation and severity of disease. Serious long-term effects begin in childhood. The role of pepsin, bile acids, pancreatic enzymes, motility disorders, and food allergies have only recently been recognized. Newer diagnostic modalities include multichannel intraluminal pH/impedance, the 48 h Bravo implantable probe, and hypopharyngeal pH monitoring. While proton pump inhibitors provide superior acid suppression compared with histamine-2 blockers, variability in response and lack of efficacy for alkaline refluxate often require other therapeutic interventions. SUMMARY: Pediatric extraesophageal reflux disease has variable presentation and a gold standard test is still lacking. Primary treatment includes lifestyle and feeding changes and medical therapy. Ongoing monitoring for recurrence and agreement as to duration of therapy present significant challenges not yet standardized amongst practitioners.

UR - http://www.scopus.com/inward/record.url?scp=33750955503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750955503&partnerID=8YFLogxK

U2 - 10.1097/MOO.0b013e3280106326

DO - 10.1097/MOO.0b013e3280106326

M3 - Review article

C2 - 17099345

AN - SCOPUS:33750955503

VL - 14

SP - 387

EP - 392

JO - Current Opinion in Otolaryngology and Head and Neck Surgery

JF - Current Opinion in Otolaryngology and Head and Neck Surgery

SN - 1068-9508

IS - 6

ER -