Extraintestinal pathogenic Escherichia coli-induced acute necrotizing pneumonia in cats

R. Sura, H. J. Van Kruiningen, Chitrita Debroy, L. S. Hinckley, K. J. Greenberg, Z. Gordon, R. A. French

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Extraintestinal pathogenic Escherichia coli (ExPEC) are pathogens involved in several disease conditions, ranging from urinary tract infection to meningitis in humans and animals. They comprise epidemiologically and phylogenetically distinct strains, affecting most species and involving any organ or anatomical site. Here, we report fatal cases of necrotizing pneumonia in cats. Over a 1-week period, 13 cats from an animal shelter in Stamford, Connecticut were presented for necropsy. All had a clinical history of acute respiratory disease. The gross and microscopic findings for all the cats were consistent. Escherichia coli was uniformly isolated from the lungs of all the tested cats. All the isolates were haemolytic, genetically related as determined by enterobacterial repetitive intergenic consensus PCR, and harboured genes encoding for cytotoxic necrotizing factor-1 and fimbriae and adhesions that are characteristic of ExPEC, implying a point source clonal outbreak. As cats are common household pets, this report raises concerns regarding zoonotic potential (in either direction) for these ExPEC strains.

Original languageEnglish (US)
Pages (from-to)307-313
Number of pages7
JournalZoonoses and Public Health
Volume54
Issue number8
DOIs
StatePublished - Oct 1 2007

Fingerprint

pneumonia
Cats
cats
Escherichia coli
urinary tract diseases
meningitis
fimbriae
Pets
Zoonoses
Acute Disease
Meningitis
Urinary Tract Infections
respiratory tract diseases
pets
Disease Outbreaks
adhesion
households
necropsy
Consensus
animals

All Science Journal Classification (ASJC) codes

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Epidemiology
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Sura, R., Van Kruiningen, H. J., Debroy, C., Hinckley, L. S., Greenberg, K. J., Gordon, Z., & French, R. A. (2007). Extraintestinal pathogenic Escherichia coli-induced acute necrotizing pneumonia in cats. Zoonoses and Public Health, 54(8), 307-313. https://doi.org/10.1111/j.1863-2378.2007.01067.x
Sura, R. ; Van Kruiningen, H. J. ; Debroy, Chitrita ; Hinckley, L. S. ; Greenberg, K. J. ; Gordon, Z. ; French, R. A. / Extraintestinal pathogenic Escherichia coli-induced acute necrotizing pneumonia in cats. In: Zoonoses and Public Health. 2007 ; Vol. 54, No. 8. pp. 307-313.
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Sura, R, Van Kruiningen, HJ, Debroy, C, Hinckley, LS, Greenberg, KJ, Gordon, Z & French, RA 2007, 'Extraintestinal pathogenic Escherichia coli-induced acute necrotizing pneumonia in cats', Zoonoses and Public Health, vol. 54, no. 8, pp. 307-313. https://doi.org/10.1111/j.1863-2378.2007.01067.x

Extraintestinal pathogenic Escherichia coli-induced acute necrotizing pneumonia in cats. / Sura, R.; Van Kruiningen, H. J.; Debroy, Chitrita; Hinckley, L. S.; Greenberg, K. J.; Gordon, Z.; French, R. A.

In: Zoonoses and Public Health, Vol. 54, No. 8, 01.10.2007, p. 307-313.

Research output: Contribution to journalArticle

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Sura R, Van Kruiningen HJ, Debroy C, Hinckley LS, Greenberg KJ, Gordon Z et al. Extraintestinal pathogenic Escherichia coli-induced acute necrotizing pneumonia in cats. Zoonoses and Public Health. 2007 Oct 1;54(8):307-313. https://doi.org/10.1111/j.1863-2378.2007.01067.x