Extraventricular Neurocytoma and Ganglioneurocytoma: Advanced MR Imaging, Histopathological, and Chromosomal Findings

Seyed Ali Nabavizadeh; Sanjeev Chawla; Jennifer Baccon; Paul J. Zhang; Harish Poptani; Elias R. Melhem; Arastoo Vossough

doi:10.1111/jon.12081

Extraventricular Neurocytoma and Ganglioneurocytoma: Advanced MR Imaging, Histopathological, and Chromosomal Findings

Seyed Ali Nabavizadeh, Sanjeev Chawla, Jennifer Baccon, Paul J. Zhang, Harish Poptani, Elias R. Melhem, Arastoo Vossough

Department of Pathology and Laboratory Medicine

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Extraventricular neurocytoma and ganglioneurocytoma are rare intra-axial brain neoplasms that are now recognized as distinct entities in the 2007 WHO classification of brain tumors. We describe the conventional MR imaging, perfusion MRI, proton MR spectroscopy (1H MRS), histopathology, immunohistochemistry, and chromosomal analysis in two cases of these tumors, with some features which have not been previously well described. Both tumor types demonstrated markedly elevated cerebral blood volume on perfusion MRI and had 1p19q chromosomal codeletions. Both tumor types showed an elevated Cho/Cr ratio, but extraventricular ganglioneurocytoma showed a preserved NAA/Cr ratio. These tumors should be considered in the differential diagnosis of intra-axial brain tumors.

Original language	English (US)
Pages (from-to)	613-616
Number of pages	4
Journal	Journal of Neuroimaging
Volume	24
Issue number	6
DOIs	https://doi.org/10.1111/jon.12081
State	Published - Nov 1 2014

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging
Clinical Neurology

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10.1111/jon.12081

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title = "Extraventricular Neurocytoma and Ganglioneurocytoma: Advanced MR Imaging, Histopathological, and Chromosomal Findings",

abstract = "Extraventricular neurocytoma and ganglioneurocytoma are rare intra-axial brain neoplasms that are now recognized as distinct entities in the 2007 WHO classification of brain tumors. We describe the conventional MR imaging, perfusion MRI, proton MR spectroscopy (1H MRS), histopathology, immunohistochemistry, and chromosomal analysis in two cases of these tumors, with some features which have not been previously well described. Both tumor types demonstrated markedly elevated cerebral blood volume on perfusion MRI and had 1p19q chromosomal codeletions. Both tumor types showed an elevated Cho/Cr ratio, but extraventricular ganglioneurocytoma showed a preserved NAA/Cr ratio. These tumors should be considered in the differential diagnosis of intra-axial brain tumors.",

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Extraventricular Neurocytoma and Ganglioneurocytoma : Advanced MR Imaging, Histopathological, and Chromosomal Findings. / Nabavizadeh, Seyed Ali; Chawla, Sanjeev; Baccon, Jennifer; Zhang, Paul J.; Poptani, Harish; Melhem, Elias R.; Vossough, Arastoo.

In: Journal of Neuroimaging, Vol. 24, No. 6, 01.11.2014, p. 613-616.

Research output: Contribution to journal › Article › peer-review

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AU - Zhang, Paul J.

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AU - Melhem, Elias R.

AU - Vossough, Arastoo

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