Extraventricular Neurocytoma and Ganglioneurocytoma: Advanced MR Imaging, Histopathological, and Chromosomal Findings

Seyed Ali Nabavizadeh, Sanjeev Chawla, Jennifer Baccon, Paul J. Zhang, Harish Poptani, Elias R. Melhem, Arastoo Vossough

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Extraventricular neurocytoma and ganglioneurocytoma are rare intra-axial brain neoplasms that are now recognized as distinct entities in the 2007 WHO classification of brain tumors. We describe the conventional MR imaging, perfusion MRI, proton MR spectroscopy (1H MRS), histopathology, immunohistochemistry, and chromosomal analysis in two cases of these tumors, with some features which have not been previously well described. Both tumor types demonstrated markedly elevated cerebral blood volume on perfusion MRI and had 1p19q chromosomal codeletions. Both tumor types showed an elevated Cho/Cr ratio, but extraventricular ganglioneurocytoma showed a preserved NAA/Cr ratio. These tumors should be considered in the differential diagnosis of intra-axial brain tumors.

Original languageEnglish (US)
Pages (from-to)613-616
Number of pages4
JournalJournal of Neuroimaging
Volume24
Issue number6
DOIs
Publication statusPublished - Nov 1 2014

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Nabavizadeh, S. A., Chawla, S., Baccon, J., Zhang, P. J., Poptani, H., Melhem, E. R., & Vossough, A. (2014). Extraventricular Neurocytoma and Ganglioneurocytoma: Advanced MR Imaging, Histopathological, and Chromosomal Findings. Journal of Neuroimaging, 24(6), 613-616. https://doi.org/10.1111/jon.12081