TY - JOUR
T1 - Extraventricular Neurocytoma and Ganglioneurocytoma
T2 - Advanced MR Imaging, Histopathological, and Chromosomal Findings
AU - Nabavizadeh, Seyed Ali
AU - Chawla, Sanjeev
AU - Baccon, Jennifer
AU - Zhang, Paul J.
AU - Poptani, Harish
AU - Melhem, Elias R.
AU - Vossough, Arastoo
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Extraventricular neurocytoma and ganglioneurocytoma are rare intra-axial brain neoplasms that are now recognized as distinct entities in the 2007 WHO classification of brain tumors. We describe the conventional MR imaging, perfusion MRI, proton MR spectroscopy (1H MRS), histopathology, immunohistochemistry, and chromosomal analysis in two cases of these tumors, with some features which have not been previously well described. Both tumor types demonstrated markedly elevated cerebral blood volume on perfusion MRI and had 1p19q chromosomal codeletions. Both tumor types showed an elevated Cho/Cr ratio, but extraventricular ganglioneurocytoma showed a preserved NAA/Cr ratio. These tumors should be considered in the differential diagnosis of intra-axial brain tumors.
AB - Extraventricular neurocytoma and ganglioneurocytoma are rare intra-axial brain neoplasms that are now recognized as distinct entities in the 2007 WHO classification of brain tumors. We describe the conventional MR imaging, perfusion MRI, proton MR spectroscopy (1H MRS), histopathology, immunohistochemistry, and chromosomal analysis in two cases of these tumors, with some features which have not been previously well described. Both tumor types demonstrated markedly elevated cerebral blood volume on perfusion MRI and had 1p19q chromosomal codeletions. Both tumor types showed an elevated Cho/Cr ratio, but extraventricular ganglioneurocytoma showed a preserved NAA/Cr ratio. These tumors should be considered in the differential diagnosis of intra-axial brain tumors.
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U2 - 10.1111/jon.12081
DO - 10.1111/jon.12081
M3 - Article
C2 - 24787229
AN - SCOPUS:84938523359
VL - 24
SP - 613
EP - 616
JO - Journal of Neuroimaging
JF - Journal of Neuroimaging
SN - 1051-2284
IS - 6
ER -