Extreme sleep durations and increased C-reactive protein

Effects of sex and ethnoracial group

Michael A. Grandner, Orfeu M. Buxton, Nicholas Jackson, Megan Sands-Lincoln, Abhishek Pandey, Girardin Jean-Louis

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Study Objectives: We hypothesize that extremes of sleep duration are associated with elevated C-reactive protein (CRP), a pro-inflammatory marker for cardiovascular disease risk. Design: Crosssectional. Setting: Population-based research. Participants: Nationally representative sample of 2007-2008 National Health and Nutrition Examination Survey participants (n = 5,587 adults). Interventions: None. Measurements and Results: Associations between CRP and self-reported total sleep time (TST) were examined. Explanatory models considered contributions of sex, age, race/ethnicity, body mass index (BMI), and BMI squared (BMI2). Models also explored the role of insomnia symptoms, sleep apnea, active medical illness, and antidiabetic/antihypertensive treatment. Differential patterns among race/ethnicity groups were examined using interactions and stratified analyses. Nonlinear relationships between CRP and TST were assessed using polynomial and multinomial regression models (< 5, 5, 6, 7, 8, 9, and > 9 h). Linear and squared terms were significant in all models in the complete sample, with notable differences by sex and ethnoracial group. Overall, in models adjusted for sociodemographics and BMI, different patterns were observed for non-Hispanic white (elevated CRP for < 5 h and > 9 h), black/African-American (elevated CRP for < 5 h and 8 h), Hispanic/Latino (elevated CRP for > 9 h), and Asian/Other (higher in 9 and > 9 h and lower in 5 h and 6 h) groups. Ethnoracial groups also demonstrated patterning by sex. Conclusion: In a representative sample of American adults, elevated CRP was associated with extreme sleep durations. Sex, race/ethnicity, sleep disorders, and medical comorbidity influenced these associations. Differences in CRP along these dimensions should be considered in future research on sleep related disparities influencing cardiometabolic disease risk.

Original languageEnglish (US)
Pages (from-to)769-779
Number of pages11
JournalSleep
Volume36
Issue number5
DOIs
StatePublished - May 1 2013

Fingerprint

C-Reactive Protein
Sleep
Body Mass Index
Nutrition Surveys
Sleep Apnea Syndromes
Sleep Initiation and Maintenance Disorders
Hypoglycemic Agents
Sex Characteristics
African Americans
Antihypertensive Agents
Comorbidity
Cardiovascular Diseases
Research
Population

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Physiology (medical)

Cite this

Grandner, M. A., Buxton, O. M., Jackson, N., Sands-Lincoln, M., Pandey, A., & Jean-Louis, G. (2013). Extreme sleep durations and increased C-reactive protein: Effects of sex and ethnoracial group. Sleep, 36(5), 769-779. https://doi.org/10.5665/sleep.2646
Grandner, Michael A. ; Buxton, Orfeu M. ; Jackson, Nicholas ; Sands-Lincoln, Megan ; Pandey, Abhishek ; Jean-Louis, Girardin. / Extreme sleep durations and increased C-reactive protein : Effects of sex and ethnoracial group. In: Sleep. 2013 ; Vol. 36, No. 5. pp. 769-779.
@article{d4a91527c3954c049de6deae1e0484af,
title = "Extreme sleep durations and increased C-reactive protein: Effects of sex and ethnoracial group",
abstract = "Study Objectives: We hypothesize that extremes of sleep duration are associated with elevated C-reactive protein (CRP), a pro-inflammatory marker for cardiovascular disease risk. Design: Crosssectional. Setting: Population-based research. Participants: Nationally representative sample of 2007-2008 National Health and Nutrition Examination Survey participants (n = 5,587 adults). Interventions: None. Measurements and Results: Associations between CRP and self-reported total sleep time (TST) were examined. Explanatory models considered contributions of sex, age, race/ethnicity, body mass index (BMI), and BMI squared (BMI2). Models also explored the role of insomnia symptoms, sleep apnea, active medical illness, and antidiabetic/antihypertensive treatment. Differential patterns among race/ethnicity groups were examined using interactions and stratified analyses. Nonlinear relationships between CRP and TST were assessed using polynomial and multinomial regression models (< 5, 5, 6, 7, 8, 9, and > 9 h). Linear and squared terms were significant in all models in the complete sample, with notable differences by sex and ethnoracial group. Overall, in models adjusted for sociodemographics and BMI, different patterns were observed for non-Hispanic white (elevated CRP for < 5 h and > 9 h), black/African-American (elevated CRP for < 5 h and 8 h), Hispanic/Latino (elevated CRP for > 9 h), and Asian/Other (higher in 9 and > 9 h and lower in 5 h and 6 h) groups. Ethnoracial groups also demonstrated patterning by sex. Conclusion: In a representative sample of American adults, elevated CRP was associated with extreme sleep durations. Sex, race/ethnicity, sleep disorders, and medical comorbidity influenced these associations. Differences in CRP along these dimensions should be considered in future research on sleep related disparities influencing cardiometabolic disease risk.",
author = "Grandner, {Michael A.} and Buxton, {Orfeu M.} and Nicholas Jackson and Megan Sands-Lincoln and Abhishek Pandey and Girardin Jean-Louis",
year = "2013",
month = "5",
day = "1",
doi = "10.5665/sleep.2646",
language = "English (US)",
volume = "36",
pages = "769--779",
journal = "Sleep",
issn = "0161-8105",
publisher = "American Academy of Sleep Medicine",
number = "5",

}

Grandner, MA, Buxton, OM, Jackson, N, Sands-Lincoln, M, Pandey, A & Jean-Louis, G 2013, 'Extreme sleep durations and increased C-reactive protein: Effects of sex and ethnoracial group', Sleep, vol. 36, no. 5, pp. 769-779. https://doi.org/10.5665/sleep.2646

Extreme sleep durations and increased C-reactive protein : Effects of sex and ethnoracial group. / Grandner, Michael A.; Buxton, Orfeu M.; Jackson, Nicholas; Sands-Lincoln, Megan; Pandey, Abhishek; Jean-Louis, Girardin.

In: Sleep, Vol. 36, No. 5, 01.05.2013, p. 769-779.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Extreme sleep durations and increased C-reactive protein

T2 - Effects of sex and ethnoracial group

AU - Grandner, Michael A.

AU - Buxton, Orfeu M.

AU - Jackson, Nicholas

AU - Sands-Lincoln, Megan

AU - Pandey, Abhishek

AU - Jean-Louis, Girardin

PY - 2013/5/1

Y1 - 2013/5/1

N2 - Study Objectives: We hypothesize that extremes of sleep duration are associated with elevated C-reactive protein (CRP), a pro-inflammatory marker for cardiovascular disease risk. Design: Crosssectional. Setting: Population-based research. Participants: Nationally representative sample of 2007-2008 National Health and Nutrition Examination Survey participants (n = 5,587 adults). Interventions: None. Measurements and Results: Associations between CRP and self-reported total sleep time (TST) were examined. Explanatory models considered contributions of sex, age, race/ethnicity, body mass index (BMI), and BMI squared (BMI2). Models also explored the role of insomnia symptoms, sleep apnea, active medical illness, and antidiabetic/antihypertensive treatment. Differential patterns among race/ethnicity groups were examined using interactions and stratified analyses. Nonlinear relationships between CRP and TST were assessed using polynomial and multinomial regression models (< 5, 5, 6, 7, 8, 9, and > 9 h). Linear and squared terms were significant in all models in the complete sample, with notable differences by sex and ethnoracial group. Overall, in models adjusted for sociodemographics and BMI, different patterns were observed for non-Hispanic white (elevated CRP for < 5 h and > 9 h), black/African-American (elevated CRP for < 5 h and 8 h), Hispanic/Latino (elevated CRP for > 9 h), and Asian/Other (higher in 9 and > 9 h and lower in 5 h and 6 h) groups. Ethnoracial groups also demonstrated patterning by sex. Conclusion: In a representative sample of American adults, elevated CRP was associated with extreme sleep durations. Sex, race/ethnicity, sleep disorders, and medical comorbidity influenced these associations. Differences in CRP along these dimensions should be considered in future research on sleep related disparities influencing cardiometabolic disease risk.

AB - Study Objectives: We hypothesize that extremes of sleep duration are associated with elevated C-reactive protein (CRP), a pro-inflammatory marker for cardiovascular disease risk. Design: Crosssectional. Setting: Population-based research. Participants: Nationally representative sample of 2007-2008 National Health and Nutrition Examination Survey participants (n = 5,587 adults). Interventions: None. Measurements and Results: Associations between CRP and self-reported total sleep time (TST) were examined. Explanatory models considered contributions of sex, age, race/ethnicity, body mass index (BMI), and BMI squared (BMI2). Models also explored the role of insomnia symptoms, sleep apnea, active medical illness, and antidiabetic/antihypertensive treatment. Differential patterns among race/ethnicity groups were examined using interactions and stratified analyses. Nonlinear relationships between CRP and TST were assessed using polynomial and multinomial regression models (< 5, 5, 6, 7, 8, 9, and > 9 h). Linear and squared terms were significant in all models in the complete sample, with notable differences by sex and ethnoracial group. Overall, in models adjusted for sociodemographics and BMI, different patterns were observed for non-Hispanic white (elevated CRP for < 5 h and > 9 h), black/African-American (elevated CRP for < 5 h and 8 h), Hispanic/Latino (elevated CRP for > 9 h), and Asian/Other (higher in 9 and > 9 h and lower in 5 h and 6 h) groups. Ethnoracial groups also demonstrated patterning by sex. Conclusion: In a representative sample of American adults, elevated CRP was associated with extreme sleep durations. Sex, race/ethnicity, sleep disorders, and medical comorbidity influenced these associations. Differences in CRP along these dimensions should be considered in future research on sleep related disparities influencing cardiometabolic disease risk.

UR - http://www.scopus.com/inward/record.url?scp=84877145088&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84877145088&partnerID=8YFLogxK

U2 - 10.5665/sleep.2646

DO - 10.5665/sleep.2646

M3 - Article

VL - 36

SP - 769

EP - 779

JO - Sleep

JF - Sleep

SN - 0161-8105

IS - 5

ER -