Eyelid and scleral necrosis following bare iridium-192 seed for retinoblastoma

Ingrid U. Scott, Cathleen M. McCabe, Timothy G. Murray, Robert H. Rosa, Stuart Toledano, Arnold M. Markoe

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A 2 1/2-year-old girl with a history of bilateral retinoblastoma underwent primary enucleation of the right eye and was referred for further management of persistent tumor in the fellow eye. Previous treatment of the left eye included external beam radiotherapy, systemic chemotherapy, laser photocoagulation, cryotherapy, and direct scleral application of a bare iridium-192 radioactive seed. Examination revealed focal full-thickness necrosis of the left upper and lower eyelid and a large inferonasal viable retinoblastoma tumor with overlying retinal detachment. Systemic chemotherapy and direct laser photocoagulation were administered. Four months after presentation, the patient developed focal scleral necrosis with 360° hemorrhagic choroidal detachment. Enucleation was performed and histopathologic examination demonstrated full-thickness scleral necrosis with adjacent viable retinoblastoma tumor cells. Follow-up examinations showed no evidence of recurrent or metastatic tumor. This case is the first report of scleral necrosis following combined modality treatment of retinoblastoma.

Original languageEnglish (US)
Pages (from-to)324-326
Number of pages3
JournalOphthalmic Surgery Lasers and Imaging
Volume34
Issue number4
StatePublished - Jul 1 2003

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Iridium
Retinoblastoma
Eyelids
Seeds
Necrosis
Light Coagulation
Neoplasms
Lasers
Eye Enucleation
Drug Therapy
Cryotherapy
Retinal Detachment
Radiotherapy
Therapeutics

All Science Journal Classification (ASJC) codes

  • Surgery
  • Ophthalmology

Cite this

Scott, I. U., McCabe, C. M., Murray, T. G., Rosa, R. H., Toledano, S., & Markoe, A. M. (2003). Eyelid and scleral necrosis following bare iridium-192 seed for retinoblastoma. Ophthalmic Surgery Lasers and Imaging, 34(4), 324-326.
Scott, Ingrid U. ; McCabe, Cathleen M. ; Murray, Timothy G. ; Rosa, Robert H. ; Toledano, Stuart ; Markoe, Arnold M. / Eyelid and scleral necrosis following bare iridium-192 seed for retinoblastoma. In: Ophthalmic Surgery Lasers and Imaging. 2003 ; Vol. 34, No. 4. pp. 324-326.
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Scott, IU, McCabe, CM, Murray, TG, Rosa, RH, Toledano, S & Markoe, AM 2003, 'Eyelid and scleral necrosis following bare iridium-192 seed for retinoblastoma', Ophthalmic Surgery Lasers and Imaging, vol. 34, no. 4, pp. 324-326.

Eyelid and scleral necrosis following bare iridium-192 seed for retinoblastoma. / Scott, Ingrid U.; McCabe, Cathleen M.; Murray, Timothy G.; Rosa, Robert H.; Toledano, Stuart; Markoe, Arnold M.

In: Ophthalmic Surgery Lasers and Imaging, Vol. 34, No. 4, 01.07.2003, p. 324-326.

Research output: Contribution to journalArticle

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Scott IU, McCabe CM, Murray TG, Rosa RH, Toledano S, Markoe AM. Eyelid and scleral necrosis following bare iridium-192 seed for retinoblastoma. Ophthalmic Surgery Lasers and Imaging. 2003 Jul 1;34(4):324-326.