Fabrication and evaluation of silica-based ceramic scaffolds for hard tissue engineering applications

Sorour Sadeghzade, Rahmatollah Emadi, Fariborz Tavangarian, Mozhgan Naderi

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

In recent decades, bone scaffolds have received a great attention in biomedical applications due to their critical roles in bone tissue regeneration, vascularization, and healing process. One of the main challenges of using scaffolds in bone defects is the mechanical strength mismatch between the implant and surrounding host tissue which causes stress shielding or failure of the implant during the course of treatment. In this paper, space holder method was applied to synthesize diopside/forsterite composite scaffolds with different diopside content. During the sintering process, NaCl, as spacer agent, gradually evaporated from the system and produced desirable pore size in the scaffolds. The results showed that adding 10 wt.% diopside to forsterite can enormously improve the bioactivity, biodegradability, and mechanical properties of the composite scaffolds. The size of crystals and pores of the obtained scaffolds were measured to be in the range 70–100 nm and 100–250 μm, respectively. Composite scaffolds containing 10 wt.% diopside showed similar compressive strength and Young's modulus (4.36 ± 0.3 and 308.15 ± 7 MPa, respectively) to that of bone.

Original languageEnglish (US)
Pages (from-to)431-438
Number of pages8
JournalMaterials Science and Engineering C
Volume71
DOIs
StatePublished - Feb 1 2017

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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