Fabrication of calcium phosphate-calcium sulfate injectable bone substitute using chitosan and citric acid

Ho Yeon Song, Esfakur Rahman, Byong Taek Lee

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

In this study, an injectable bone substitute (IBS) consisting of citric acid, chitosan solution as the liquid phase and tetra calcium phosphate (TTCP), dicalcium phosphate anhydrous (DCPA) and calcium sulfate hemihydrate (CSH) powders as the solid phase was prepared. Four groups containing different percentages (0-30%) of calcium sulfate hemihydrate (CSH, CaSO4 • 0.5H2O) were investigated. Initial setting times for IBS with CSH were longer than those without CSH. The setting times for all compositions were in the range of 25-45 min. The injectability was improved by the addition of CSH in the present system. Scanning electron microscopy images showed that fiber-like crystallization appeared in the cements. The enhancement of crystallinity was confirmed by XRD profiles where the peak intensity of HAp increased with incubation time and the addition of CSH. Also, the compressive strength increased with the addition of CSH. The maximum compressive strength obtained for IBS was with 20% CSH after 28-day incubation in 100% humidity at 37°C.

Original languageEnglish (US)
Pages (from-to)935-941
Number of pages7
JournalJournal of Materials Science: Materials in Medicine
Volume20
Issue number4
DOIs
StatePublished - Apr 1 2009

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Bone Substitutes
Calcium Sulfate
Citric acid
Calcium phosphate
Chitosan
Citric Acid
Calcium
Bone
Fabrication
Injections
Compressive Strength
Compressive strength
Sulfates
calcium phosphate
Crystallization
Humidity
Electron Scanning Microscopy
Powders
Atmospheric humidity
Cements

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biophysics
  • Biomaterials
  • Biomedical Engineering

Cite this

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abstract = "In this study, an injectable bone substitute (IBS) consisting of citric acid, chitosan solution as the liquid phase and tetra calcium phosphate (TTCP), dicalcium phosphate anhydrous (DCPA) and calcium sulfate hemihydrate (CSH) powders as the solid phase was prepared. Four groups containing different percentages (0-30{\%}) of calcium sulfate hemihydrate (CSH, CaSO4 • 0.5H2O) were investigated. Initial setting times for IBS with CSH were longer than those without CSH. The setting times for all compositions were in the range of 25-45 min. The injectability was improved by the addition of CSH in the present system. Scanning electron microscopy images showed that fiber-like crystallization appeared in the cements. The enhancement of crystallinity was confirmed by XRD profiles where the peak intensity of HAp increased with incubation time and the addition of CSH. Also, the compressive strength increased with the addition of CSH. The maximum compressive strength obtained for IBS was with 20{\%} CSH after 28-day incubation in 100{\%} humidity at 37°C.",
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Fabrication of calcium phosphate-calcium sulfate injectable bone substitute using chitosan and citric acid. / Song, Ho Yeon; Rahman, Esfakur; Lee, Byong Taek.

In: Journal of Materials Science: Materials in Medicine, Vol. 20, No. 4, 01.04.2009, p. 935-941.

Research output: Contribution to journalArticle

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