Fabrication of ordered sub-micron topographies on large-area poly(urethane urea) by two-stage replication molding

Keith R. Milner, Mallory Balmer, Henry J. Donahue, Alan J. Snyder, Christopher Siedlecki

Research output: Contribution to journalConference article

3 Citations (Scopus)

Abstract

It has been established that material surface topography can have a significant effect on biological cell adhesion, in the absence of changes in surface chemistry. Such investigations were typically performed using surface features with size on the order of microns, comparable to the dimensions of the cells. It has been demonstrated that sub-micron sized topographies that cannot be created via contact lithography also influence cell behavior. The ability to affect cell adhesion is a prime consideration in the development of novel biomaterials. This study reports a two-stage replication molding process for fabricating ordered sub-micron sized features over a large area of biomedical polyether(urethane urea). Such a technique has great applicability in the area of long-term implantable materials as a method for influencing cell-material interactions.

Original languageEnglish (US)
Article numberR2.8
Pages (from-to)339-344
Number of pages6
JournalMaterials Research Society Symposium Proceedings
Volume820
StatePublished - Dec 1 2004
EventNanoengineered Assemblies and Advanced Micro/Nanosystems - San Francisco, CA, United States
Duration: Apr 13 2004Apr 16 2004

Fingerprint

urethanes
Urethane
ureas
Urea
Molding
Topography
topography
Cell adhesion
Fabrication
fabrication
cells
adhesion
Polyethers
Biocompatible Materials
Surface topography
Surface chemistry
Biomaterials
Lithography
lithography
chemistry

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

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abstract = "It has been established that material surface topography can have a significant effect on biological cell adhesion, in the absence of changes in surface chemistry. Such investigations were typically performed using surface features with size on the order of microns, comparable to the dimensions of the cells. It has been demonstrated that sub-micron sized topographies that cannot be created via contact lithography also influence cell behavior. The ability to affect cell adhesion is a prime consideration in the development of novel biomaterials. This study reports a two-stage replication molding process for fabricating ordered sub-micron sized features over a large area of biomedical polyether(urethane urea). Such a technique has great applicability in the area of long-term implantable materials as a method for influencing cell-material interactions.",
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Fabrication of ordered sub-micron topographies on large-area poly(urethane urea) by two-stage replication molding. / Milner, Keith R.; Balmer, Mallory; Donahue, Henry J.; Snyder, Alan J.; Siedlecki, Christopher.

In: Materials Research Society Symposium Proceedings, Vol. 820, R2.8, 01.12.2004, p. 339-344.

Research output: Contribution to journalConference article

TY - JOUR

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AU - Milner, Keith R.

AU - Balmer, Mallory

AU - Donahue, Henry J.

AU - Snyder, Alan J.

AU - Siedlecki, Christopher

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