Facile benzo-ring construction via palladium-catalyzed functionalization of unactivated sp3 C-H bonds under mild reaction conditions

Yiqing Feng, Yuji Wang, Bradley Landgraf, Shi Liu, Gong Chen

Research output: Contribution to journalArticlepeer-review

126 Scopus citations

Abstract

(Equation Presented). A practical synthetic method for the annulation of benzo-rings by the intramolecular coupling of an aryl iodide and a methylene C-H bond is described. The palladium-catalyzed C-H functionalization is directed by an aminoquinoline carboxamide group, which can be easily installed and removed. High yields and broad substrate scope were achieved. An additive of ortho-phenyl benzoic acid, identified from a systematic screening, functions as a critical ligand for the catalytic process under mild condition, even at near room temperature.

Original languageEnglish (US)
Pages (from-to)3414-3417
Number of pages4
JournalOrganic Letters
Volume12
Issue number15
DOIs
StatePublished - Aug 6 2010

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Facile benzo-ring construction via palladium-catalyzed functionalization of unactivated sp<sup>3</sup> C-H bonds under mild reaction conditions'. Together they form a unique fingerprint.

Cite this