Facile synthesis of @-tide β-strand peptidomimetics: Improved assembly in solution and on solid phase

Scott T. Phillips, Giovanni Piersanti, Matthias Rüth, Niko Gubernator, Bettina Van Lengerich, Paul A. Bartlett

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

(Chemical equation presented) The synthesis of @-tide β-strand peptidomimetics has been improved such that oligomers now can be obtained from solution- and solid-phase synthesis protocols approaching the efficiency and flexibility of peptide chemistry. These methods enable the synthesis of @-tide oligomers with a variety of amino acids and with lengths up to 13 units.

Original languageEnglish (US)
Pages (from-to)4483-4485
Number of pages3
JournalOrganic Letters
Volume6
Issue number24
DOIs
StatePublished - Nov 25 2004

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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