Abstract
Object. The authors examine the validity of single-unit neuronal recordings as a method of differentiating the globus pallidus intemus (GPi) from the GP externus (GPe) in Parkinson Disease. Methods. One hundred twenty-eight recordings of apparent single-unit activity used to help guide final electrode placement in eight patients who underwent pallidotomy were analyzed using sophisticated spike sorting methods, and 185 neurons were characterized for mean firing frequency and percent of firing within bursts. In addition, the total spectral power was calculated on the full measured waveform for each of 128 samples without spike sorting. No correlation was identified between these measures of neuronal activity and depth within the GP. Conclusions. These results call into question the validity of relying on single-unit activity and microelectrode recordings in the operating room to localize lesion or electrode placement within the GPi during stereotactic pallidal surgery.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 119-128 |
| Number of pages | 10 |
| Journal | Journal of neurosurgery |
| Volume | 97 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2002 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Clinical Neurology
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Failure of single-unit neuronal activity to differentiate globus pallidus internus and externus in Parkinson disease. / Schiff, Steven J.; Dunagan, Brian K.; Worth, Robert M.
In: Journal of neurosurgery, Vol. 97, No. 1, 01.01.2002, p. 119-128.Research output: Contribution to journal › Article
TY - JOUR
T1 - Failure of single-unit neuronal activity to differentiate globus pallidus internus and externus in Parkinson disease
AU - Schiff, Steven J.
AU - Dunagan, Brian K.
AU - Worth, Robert M.
PY - 2002/1/1
Y1 - 2002/1/1
N2 - Object. The authors examine the validity of single-unit neuronal recordings as a method of differentiating the globus pallidus intemus (GPi) from the GP externus (GPe) in Parkinson Disease. Methods. One hundred twenty-eight recordings of apparent single-unit activity used to help guide final electrode placement in eight patients who underwent pallidotomy were analyzed using sophisticated spike sorting methods, and 185 neurons were characterized for mean firing frequency and percent of firing within bursts. In addition, the total spectral power was calculated on the full measured waveform for each of 128 samples without spike sorting. No correlation was identified between these measures of neuronal activity and depth within the GP. Conclusions. These results call into question the validity of relying on single-unit activity and microelectrode recordings in the operating room to localize lesion or electrode placement within the GPi during stereotactic pallidal surgery.
AB - Object. The authors examine the validity of single-unit neuronal recordings as a method of differentiating the globus pallidus intemus (GPi) from the GP externus (GPe) in Parkinson Disease. Methods. One hundred twenty-eight recordings of apparent single-unit activity used to help guide final electrode placement in eight patients who underwent pallidotomy were analyzed using sophisticated spike sorting methods, and 185 neurons were characterized for mean firing frequency and percent of firing within bursts. In addition, the total spectral power was calculated on the full measured waveform for each of 128 samples without spike sorting. No correlation was identified between these measures of neuronal activity and depth within the GP. Conclusions. These results call into question the validity of relying on single-unit activity and microelectrode recordings in the operating room to localize lesion or electrode placement within the GPi during stereotactic pallidal surgery.
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UR - http://www.scopus.com/inward/citedby.url?scp=0036288497&partnerID=8YFLogxK
U2 - 10.3171/jns.2002.97.1.0119
DO - 10.3171/jns.2002.97.1.0119
M3 - Article
C2 - 12134901
AN - SCOPUS:0036288497
VL - 97
SP - 119
EP - 128
JO - Journal of Neurosurgery
JF - Journal of Neurosurgery
SN - 0022-3085
IS - 1
ER -